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US 7,368,577 B2Granted
Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
AssigneeRenopharm Ltd.
InventorsPeter Assaf, Elham Gazaleen-Mariee, Michael Naveh
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Abstract
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
Claims4
An NO-donating compound having the general formula I:
- wherein:
- A is absent;
- X is a non substituted phenyl;
- B is an ethylene chain;
- Y is an —ONO2 group;
- and
- Z is methyl, the compound being 4-methyl-5-(2-nitrooxy-ethyl)-2-phenyl-thiazole.
4 more elements
Dependencies are inferred from the claim text.