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US 7,365,085 B2Granted
Compounds and methods
AssigneeSmithKline Beecham Corporation
InventorsAjita Bhat, John Jeffrey McAtee, Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph Marino, Michael J. Neeb, Robert A. Stavenger
Life of this patent
Estimating the term…
Abstract
Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
Claims36
A compound of Formula I:
- wherein:
- X is selected from C1-C8 alkyl, halo, —OR10, —NR14R15, nitro, cyano, —COOR10, —COR13, —OCOR13, —N(R17)COR13, —N(R17)CONR14R15, —N(R17)COOR13, —SO3H, —SO2NR14R15, —C(═NR17)NR14R15, —N(R17)SO2R16, and a 5 or 6-membered heterocyclic group;
- or X and an adjacent R3, taken together with the atoms to which they are bonded, form an alkylenedioxy moiety;
- Z is CH, CR3 or N, wherein when Z is CH or CR3, k is 0-4 and t is 0 or 1, and when Z is N, k is 0-3 and t is 0;
- Y is selected from —O—, —S—, —N(R10)-, and —C(R4)(R5)—;
- W1 is selected from C3-C8 cycloalkyl, aryl and Het, wherein said C3-C8 cycloalkyl, aryl and Het are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-CO2R10, —C0-C6 alkyl-C(O)SR10, —C0-C6 alkyl-CONR11R12, —C0-C6 alkyl-COR13, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-SR10, —C0-C6 alkyl-OR10, —C0-C6 alkyl-SO3H, —C0-C6 alkyl-SO2NR11R12, —C0-C6 alkyl-SO2R10, —C0-C6 alkyl-SOR13, —C0-C6 alkyl-OCOR13, —C0-C6 alkyl-OC(O)NR11R12, —C0-C6 alkyl-OC(O)OR13, —C0-C6 alkyl-NR11C(O)OR13, —C0-C6 alkyl-NR11C(O)NR11R12, and —C0-C6 alkyl-NR11COR13, where said C1-C6 alkyl, is optionally unsubstituted or substituted by one or more halo substituents;
- W2 is selected from H, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-SR10, —C0-C6 alkyl-OR10, —C0-C6 alkyl-CO2R10, —C0-C6 alkyl-C(O)SR10, —C0-C6 alkyl-CONR11R12, —C0-C6 alkyl-COR13, —C0-C6 alkyl-OCOR13, —C0-C6 alkyl-OCONR11R12, —C0-C6 alkyl-NR11CONR11R12, —C0-C6 alkyl-NR11COR13, —C0-C6 alkyl-Het, —C0-C6 alkyl-aryl and —C0-C6 alkyl-C3-C7 cycloalkyl, wherein said C1-C6 alkyl is optionally unsubstituted or substituted by one or more halo substituents, and wherein the C3-C7 cycloalkyl, aryl and Het moieties of said —C0-C6 alkyl-Het, —C0-C6 alkyl-aryl and —C0-C6 alkyl-C3-C7 cycloalkyl are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-CO2R10, —C0-C6 alkyl-C(O)SR10, —C0-C6 alkyl-CONR11R12, —C0-C6 alkyl-COR13, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-SR10, —C0-C6 alkyl-OR10, —C0-C6 alkyl-SO3H, —C0-C6 alkyl-SO2NR11R12, —C0-C6 alkyl-SO2R10, —C0-C6 alkyl-SOR13, —C0-C6 alkyl-OCOR13, —C0-C6 alkyl-OC(O)NR11R12, —C0-C6 alkyl-OC(O)OR13, —C0-C6 alkyl-NR11C(O)OR13, —C0-C6 alkyl-NR11C(O)NR11R12, and —C0-C6 alkyl-NR11COR13, where said C1-C6 alkyl, is optionally unsubstituted or substituted by one or more halo substituents;
- W3 is selected from the group consisting of:
- H, halo, C1-C6 alkyl, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-SR10, —C0-C6 alkyl-OR10, —C0-C6 alkyl-CO2R10, —C0-C6 alkyl-C(O)SR10, —C0-C6 alkyl-CONR11R12, —C0-C6 alkyl-COR13, —C0-C6 alkyl-OCOR13, —C0-C6 alkyl-OCONR11R12, —C0-C6 alkyl-NR11CONR11R12, —C0-C6 alkyl-NR11COR13, —C0-C6 alkyl-Het, —C1-C6 alkyl-aryl and —C1-C6 alkyl-C3-C7 cycloalkyl, wherein said C1-C6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;
- Q is selected from C3-C8 cycloalkyl, Ar and Het;
- wherein said C3-C8 cycloalkyl, Ar and Het are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-CO2R10, —C0-C6 alkyl-C(O)SR10, —C0-C6 alkyl-CONR11R12, —C0-C6 alkyl-COR13, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-SR10, —C0-C6 alkyl-OR10, —C0-C6 alkyl-SO3H, —C0-C6 alkyl-SO2NR11R12, —C0-C6 alkyl-SO2R10, —C0-C6 alkyl-SOR13, —C0-C6 alkyl-OCOR13, —C0-C6 alkyl-OC(O)NR11R12, —C0-C6 alkyl-OC(O)OR13, —C0-C6 alkyl-NR11C(O)OR13, —C0-C6 alkyl-NR11C(O)NR11R12, and —C0-C6 alkyl-NR11COR13, where said C1-C6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;
- p is 0-8;
- n is 3;
- m is 0 or 1;
- q is 0 or 1;
- t is 0 or 1;
- each R1 and R2 are independently selected from H, halo, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-OR10, —C0-C6 alkyl-SR10, —C1-C6 alkyl-Het, —C1-C6 alkyl-Ar and —C1-C6 alkyl-C3-C7 cycloalkyl, or R1 and R2 together with the carbon to which they are attached form a 3-5 membered carbocyclic or heterocyclic ring, wherein said heterocyclic ring contains one, or more heteroatoms selected from N, O, and S, where any of said C1-C6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;
- each R3 is the same or different and is independently selected from halo, cyano, nitro, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-Ar, —C0-C6 alkyl-Het, —C0-C6 alkyl-C3-C7 cycloalkyl, —C0-C6 alkyl-CO2R10, —C0-C6 alkyl-C(O)SR10, —C0-C6 alkyl-CONR11R12, —C0-C6 alkyl-COR13, —C0-C6 alkyl-NR11R12, —C0-C6 alkyl-SR10, —C0-C6 alkyl-OR10, —C0-C6 alkyl-SO3H, —C0-C6 alkyl-SO2NR11R12, —C0-C6 alkyl-SO2R10, —C0-C6 alkyl-SOR13, —C0-C6 alkyl-OCOR13, —C0-C6 alkyl-OC(O)NR11R12, —C0-C6 alkyl-OC(O)OR13, —C0-C6 alkyl-NR11C(O)OR13, —C0-C6 alkyl-NR11C(O)NR11R12, and —C0-C6 alkyl-NR11COR13, wherein said C1-C6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;
- each R4 and R5 is independently selected from H, halo, C1-C6 alkyl, —C0-C6 alkyl-Het, —C0-C6 alkyl-Ar and —C0-C6 alkyl-C3-C7 cycloalkyl;
- R6 and R7 are each independently selected from H, halo, C1-C6 alkyl, —C0-C6 alkyl-Het, —C0-C6 alkyl-Ar and —C0-C6 alkyl-C3-C7 cycloalkyl;
- R8 and R9 are each independently selected from H, halo, C1-C6 alkyl, —C0-C6 alkyl-Het, —C0-C6 alkyl-Ar and —C0-C6 alkyl-C3-C7 cycloalkyl;
- R10 is selected from H, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-Ar, —C0-C6 alkyl-Het and —C0-C6 alkyl-C3-C7 cycloalkyl;
- each R11 and each R12 are independently selected from H, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-Ar, —C0-C6 alkyl-Het and —C0-C6 alkyl-C3-C7 cycloalkyl, or R11 and R12 together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S;
- R13 is selected from C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-Ar, —C0-C6 alkyl-Het and —C0-C6 alkyl-C3-C7 cycloalkyl;
- R14 and R15 are each independently selected from H, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, —C0-C6 alkyl-Ar, —C0-C6 alkyl-Het, —C0-C6 alkyl-C3-C7 cycloalkyl, —C0-C6 alkyl-O—Ar, —C0-C6 alkyl-O-Het, —C0-C6 alkyl-O—C3-C7 cycloalkyl, —C0-C6 alkyl-S(O)x—C1-C6 alkyl, —C0-C6 alkyl-S(O)x—Ar, —C0-C6 alkyl-S(O)x-Het, —C0-C6 alkyl-S(O)x—C3-C7 cycloalkyl, —C0-C6 alkyl-NH-Het, —C0-C6 alkyl-NH—C3-C7 cycloalkyl, —C0-C6 alkyl-N(C1-C4 alkyl)-Ar, —C0-C6 alkyl-N(C1-C4 alkyl)-Het, —C0-C6 alkyl-N(C1-C4 alkyl)-C3-C7 cycloalkyl, —C0-C6 alkyl-Ar, —C0-C6 alkyl-Het and —C0-C6 alkyl-C3-C7 cycloalkyl, where x is 0, 1 or 2, or R14 and R15, together with the nitrogen to which they are attached, form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S, wherein said C1-C6 alkyl is optionally substituted by one or more of the substituents independently selected from the group halo, —OH, —SH, —NH2, —NH(unsubstituted C1-C6 alkyl), —N(unsubstituted C1-C6 alkyl)(unsubstituted C1-C6 alkyl), unsubstituted —OC1-C6 alkyl, —CO2H, —CO2(unsubstituted C1-C6 alkyl), —CONH2, —CONH(unsubstituted C1-C6 alkyl), —CON(unsubstituted C1-C6 alkyl)(unsubstituted C1-C6 alkyl), —SO3H, —SO2NH2, —SO2NH(unsubstituted C1-C6 alkyl) and —SO2N(unsubstituted C1-C6 alkyl)(unsubstituted C1-C6 alkyl);
- R16 is C1-C6 alkyl, —C0-C6 alkyl-Ar or —C0-C6 alkyl-Het;
- and
- R17 is H, C1-C6 alkyl, —C0-C6 alkyl-Ar or —C0-C6 alkyl-Het;
- wherein each Ar or aryl independently represent a substituted or unsubstituted carbocyclic aromatic group, which may be optionally fused to another carbocyclic aromatic group moiety or to a cycloalkyl group moiety, wherein said Ar or aryl is optionally substituted by one or more of the substituents independently selected from the group halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, —C0-C6 alkyl-OH, —C0-C6 alkyl-SH, —C0-C6 alkyl-NR′R″, C3-C6 alkenyl, —OC1-C6alkyl, —OC1-C6 alkenyl, —C0-C6 alkyl-COR′, —C0-C6 alkyl-CO2R′, —C0-C6 alkyl-CONR′R″, —OC0-C6 alkyl-CO2H, —OC2-C6 alkyl-NR′R″, —C0-C6 alkyl-C(═NR′)NR′R″, and —C0-C6 alkyl-SO2NR′R″, wherein each R′ and R″ are independently selected from H and unsubstituted C1-C6 alkyl,
- each Het independently represents a monocyclic 5- to 7-membered, a bicyclic 7- to 10-membered or a tricyclic 11- to 18-membered heterocyclic ring group which is saturated, unsaturated or aromatic, and consists of carbon atoms and from one to three heteroatoms selected from N, O and S, wherein the N or S heteroatoms of said Het are optionally oxidized or the N heteroatom is optionally quaternized, wherein said Het is optionally unsubstituted or substituted by one or more of the substituents independently selected from the group halo, cyano, C1-C6 alkyl (which specifically includes C1-C6 haloalkyl, —C0-C6 alkyl-OH, —C0-C6 alkyl-SH and —C0-C6 alkyl-NR′R″), C3-C6 alkenyl, oxo, —OC1-C6alkyl, —OC1-C6 alkenyl, —C0-C6 alkyl-COR′, —C0-C6 alkyl-CO2R′, —C0-C6 alkyl-CONR′R″, —OC0-C6 alkyl-CO2H, —OC2-C6 alkyl-NR′R″, —C0-C6 alkyl-C(═NR′)NR′R″ and —C0-C6 alkyl-SO2NR′R″, wherein each R′ and R″ are independently selected from H and unsubstituted C1-C6 alkyl;
- provided that X is not COOR10 when Y is —O—, p is 0-8, n is 3, m is 1, q is 0 or 1, t is 0, each R1 and R2 is independently selected from H, C1-C6 alkyl, —OH, —O—C1-C6 alkyl, —SH, and —S—C1-C6 alkyl, each R4, R5, R6, R7, R8 and R9 are independently H or C1-C4 alkyl, k is 0 or 1, W3 is H, W1 and W2 are each independently selected from C3-C8 cycloalkyl and aryl and R3 and Q are as defined above;
- or
- provided that the compound is not
- 5-[3-[[(3,4-dichlorophenyl)methyl][2-(2-naphthalenyl)ethyl]amino]propoxy]-3-methoxy-1,2-benzenedicarboxylic acid, or
- 5-[3-[[(3,4-dichlorophenyl)methyl][2-(2-naphthalenyl)ethyl]amino]propoxy]-3-methoxy-1,2-benzenedicarboxylic acid, dimethyl ester;
- or a pharmaceutically acceptable salt or hydrate thereof.
33 more elements
A compound selected from:
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-dephenylethyl)amino]propoxy}phenyl)-ethanol;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-phenyl)acetic acid, N-oxide;
- (3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-bromobenzene;
- (4-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-bromobenzene;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenylethyl)-{3-[3-(1,2,4-triazol-3-ylmethyl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2-cyclohexyl-2-phenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine;
- (S)-2-Chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine;
- (R)-(2-Chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine;
- (S)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid;
- (R)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid;
- Chloro-3-(trifluoromethyl)benzyl]naphthalen-1-ylmethyl-amino]propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]-benzylamino]propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)-benzyl]phenethylamino]propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-hydroxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-acetoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid;
- Benzoic acid 2-[3-(3-carboxymethyl-phenoxy)-{2-chloro-3-(trifluoromethyl)benzyl}propylamino]-1-phenyl ethyl ester;
- (3-{3-[(2-Acetoxy-2-phenyl-ethyl)-(2-chloro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetc acid methyl ester;
- Benzoic acid 2-[3-(3-methoxycarbonylmethyl-phenoxy){2-chloro-3-(trifluoromethyl)benzyl}propylamino]-1-phenyl ethyl ester;
- (3-{4-[(2-Chloro-3-(trifluoromethyl)benzyl)-(2,2-diphenylethyl)-amino]butyl}phenyl)-acetic acid;
- (3-{3-[(4-Fluoro-3-methyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[Benzo[1,3]dioxol-5-ylmethyl-((R)-2-phenyl-propyl)-amino]-propoxy}phenyl)-acetic acid;
- (3-{3-[(4-tert-Butyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[(4-Methylsulfanyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[((R)-2-Phenyl-propyl)-(2,4,5-trifluoro-benzyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[((R)-2-Phenyl-propyl)-(5-piperidin-1-yl-furan-2-ylmethyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[(4-Isopropyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-propane-1,3-diol;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-carbamic acid tert-butyl ester;
- 3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethylamino]-propoxy}-phenylamine;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-acetamide;
- Furan-2-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-amide;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-methanesulfonamide;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-benzenesulfonamide;
- 1-(2-Chloro-phenyl)-3-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-urea;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amine;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-acetamide;
- Furan-2-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amide;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-methanesulfonamide;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-benzenesulfonamide;
- 3-(2-Chloro-phenyl)-1-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-1-methyl-urea;
- Benzo[1,3]dioxole-5-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amide;
- 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-3-(3,5-dimethoxy-phenyl)-1-methyl-urea;
- Propane-1-sulfonic acid (5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-2-methyl-phenyl)-amide;
- 3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-2-methyl-phenylamine;
- 2-Chloro-5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenylamine;
- 3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-cyclopentyl-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-isopropyl-amine;
- Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-ethyl-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(3-methyl-butyl)-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-isobutyl-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(2,2,2-trifluoroethyl)-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-cyclopropylmethy-1-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(2-ethyl-butyl)-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(2,2-dimethyl-propyl)-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-hexyl-amine;
- Butyl-(3-{3[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-amine;
- [1-(3-{3-[(2-Chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl)-amino]-propoxy}-phenyl-piperidine-4-carboxylic acid;
- [1-(3-{3-[(2-Chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl)-amino]-propoxy}-phenyl-piperidine-4-yl-acetic acid;
- [4-(3-{3-[(2-Chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl-amino]-propoxy}-phenyl)-piperidin-1-yl]-acetic acid;
- rac-±-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(trifluoro-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- rac-±-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-dimethylamino-2-phenyl-ethyl)-amino]-propoxy}-phenyl)-acetic acid;
- rac-±-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-morpholin-4-yl-2-phenyl-ethyl)-amino]-propoxy}-phenyl)-acetic acid;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(6-morpholin-4-yl-pyridin-2-yloxy)-propyl]-amine;
- [3-(6-Chloro-pyridin-2-yloxy)-propyl]-(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(6-piperazin-1-yl-pyridin-2-yloxy)-propyl]-amine;
- [4-(6-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-pyridin-2-yl)-piperazin-1-yl]-acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-1-methyl-propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-1-methyl-propoxy}-phenyl)ethanol;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)ethanol;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((R)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)acetic acid;
- 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((R)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)ethanol;
- (R)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)ethanol;
- 3-{3-[(3-Chloro-2-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy-N,N-dimethyl-benzenesulfonamide;
- Cyclopropanecarboxylic acid 3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzylamide;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-isobutyramide;
- Acetic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzylcarbamoyl)-methyl ester;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-propionamide;
- 2,5-Dimethyl-2-H-pyrazole-3-carboxylic acid 3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzylamide;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-o-tolyloxy-propyl)-amine;
- 2-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzonitrile;
- [3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}benzonitrile;
- [3-(3-Chloro-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(2-methoxy-phenoxy)-propyl]-amine;
- [3-(2-Chloro-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-phenoxy-propyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-isopropyl-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(4-methoxy-phenoxy)-propyl]-amine;
- 3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenol;
- 2-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenol;
- 3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenylamine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propyl]-amine;
- 1-(3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethanone;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-phenyl-amine;
- [3-(Benzo[1,3]dioxol-5-yloxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-m-tolyloxy-propyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-methoxy-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-isobutyl-phenoxy)-propyl]-amine;
- [3-(3-Butyl-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2,2-dimethyl-propyl)-phenoxy]-propyl}-(2,2-diphenyl-ethyl)-amine;
- (4-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-methyl-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-[3-(4-dimethylaminomethyl-phenoxy)-propyl]-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(4-morpholin-4-ylmethyl-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[4-(4-methyl-piperazin-1-ylmethyl)-phenoxy]-propyl}-amine;
- (3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-methyl-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-[3-(3-dimethylaminomethyl-phenoxy)-propyl]-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-morpholin-4-ylmethyl-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(4-methyl-piperazin-1-ylmethyl)-phenoxy]-propyl}-amine;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-isopropyl-amine;
- {3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-trifluoromethyl-phenylamine;
- {3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenylamine;
- Ethanesulfonic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide;
- Propane-2-sulfonic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide;
- Methanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide;
- 2,2,2-Trifluoro-ethanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide;
- Ethanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-amide;
- 2,2,2-Trifluoro-ethanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-amide;
- N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-1,1,1-trifluoro-methanesulfonamide;
- Propane-2-sulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-amide;
- {3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methoxy-phenylamine;
- Ethanesulfonic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methoxy-phenyl)-amide;
- (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-((S)-2-phenyl-propyl amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-ethylamino-ethyl)-phenoxy]-propyl}-((S)-2-phenyl-propyl)-amine;
- (3-{(R)-3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-butoxy}-phenyl)-acetic acid;
- (3-{(S)-3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-butoxy}-phenyl)-acetic acid;
- 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-ethanol;
- 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-2-methyl-propionic acid;
- 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-2-methyl-propionic acid;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-thiophen-3-yl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-thiophen-3-yl-propyl)-amino]-propoxy}-phenyl)-ethanol;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-thiophen-2-yl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-pyridin-2-yl-propyl)-amino]-propoxy}-phenyl)-acetic acid;
- [3-(3-{(2-Chloro-3-trifluoromethyl-benzyl)-[2-(4-methyl-pyridin-2-yl)-propyl]-amino}-propoxy)-phenyl]-acetic acid;
- [3-(3-{(2-Chloro-3-trifluoromethyl-benzyl)-[3,3,3-trifluoro-2-(1H-pyrrol-2-yl)-propyl]-amino}-propoxy)-phenyl]-acetic acid;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-{3-[2-(4-methyl-piperazin-1-yl)-ethyl]-phenoxy}-propyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-methylamino-ethyl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(1H-imidazol-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-ethylamino-ethyl)-phenoxy]-propyl}-amine;
- [3-(3-{2-[(5-Bromo-thiophen-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(thiophen-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-dimethylamino-ethyl)-phenoxy]-propyl}-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-pyrrolidin-1-yl-ethyl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{(R)-1-methyl-3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{(R)-2-methyl-3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-amine;
- {3-[3-(2-Amino-ethyl)-phenoxy]-propyl}-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine;
- [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-isopropyl-amine;
- [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-propyl-amine;
- 2-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-ethanol;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(1-methyl-1H-imidazol-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-thiomorpholin-4-yl-ethyl)-phenoxy]-propyl}-amine;
- [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-acetic acid;
- [2-(3-{(R)-3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-butoxy}-phenyl)-ethylamino]-acetic acid;
- {[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-methyl-amino}-acetic acid;
- 2-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-2-methyl-propionic acid;
- (S)-2-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-propionic acid;
- (R)-1-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrrolidine-2-carboxylic acid;
- (S)-1-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrrolidine-2-carboxylic acid;
- [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrimidin-2-yl-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-morpholin-4-yl-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-piperidin-1-yl-phenoxy)-propyl]-amine;
- (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-diethyl-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2,5-dimethyl-pyrrol-1-yl)-phenoxy]-propyl}-(2,2-diphenyl-ethyl)-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-piperazin-1-yl-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-[3-(3-piperazin-1-yl-phenoxy)-propyl]-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(R)-2-methyl-3-(3-piperazin-1-yl-phenoxy)-propyl]-amine;
- [4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid;
- [4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid;
- [4-(3-((R)-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-methyl-propoxy}-phenyl)-piperazin-1-yl]-acetic acid;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(4-methyl-piperazin-1-yl)-phenoxy]-propyl}-amine;
- (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-pyrrolidin-1-yl-phenoxy)-propyl]-amine;
- (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenylamino)-acetic acid;
- [(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amino]-acetic acid;
- N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-[3-(2-methyl-2-aminopropyl)phenoxy]propylamine;
- N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxymethyl]phenoxy)propylamine, N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxy-2-methylpropyl]phenoxy)propylamine;
- N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-N-methylsulfonamidophenoxy)propylamine;
- N-(2-[2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-[3-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-[4-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-[2-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-[4-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-Phenylbutyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-[2-Methyl-2-phenyl]propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-Phenyl-3-methylbutyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-Phenylhexyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- N-(2-Phenyl-3-butynyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- (S)-N-(2-Phenyl-2-methoxyethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- (R)-N-(2-Phenyl-2-methoxyethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine;
- (R)-N-(2-Phenyl-2-methoxyethyl)-N-2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxy-2-methylpropyl]phenoxy)propylamine;
- 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-cyclobutanecarboxylic acid;
- 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-cyclopentanecarboxylic acid;
- 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-cyclopropanecarboxylic acid;
- and a pharmaceutically acceptable salt or hydrate thereof.
195 more elements
Dependencies are inferred from the claim text.