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US 7,364,895 B2Granted
Bioarray chip reaction apparatus and its manufacture
AssigneeAffymetrix, Inc.
InventorsDonald M. Besemer, Virginia W. Goss, James L. Winkler
Life of this patent
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Abstract
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
Claims28
An apparatus for mixing a fluid, the apparatus comprising:
- a first substrate comprising a first inner surface functionalized with a microarray of reactive moieties;
- a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
- at least one bubble disposed within said chamber;
- and
- means for moving the chamber so that the bubble moves relative to the fluid so effect mixing of the fluid.
2 more elements
An apparatus for mixing a fluid, the apparatus comprising:
- a first substrate comprising a first inner surface functionalized with an array of reactive moieties;
- a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
- at least one bubble disposed within said chamber;
- and
- means for moving the chamber so that the bubble moves relative to the fluid to effect mixing of the fluid.
2 more elements
Dependencies are inferred from the claim text.