Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response
AssigneeLipid Sciences, Inc.
InventorsMoiz Kitabwalla, Hassibullah Akeefe
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AssigneeLipid Sciences, Inc.
InventorsMoiz Kitabwalla, Hassibullah Akeefe
Estimating the term…
The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation of the cancer cells, a portion of the cancer cell antigens remain intact. These exposed antigens, or epitopes, foster and promote antibody production. The resulting modified cancer cell particle, or portions of the cancer cell, initiate a positive immunogenic response when administered to an animal or human and help to treat, prevent or delay the onset of cancer. The present invention provides autologous and heterologous vaccine compositions comprising the modified cancer cell with a pharmaceutically acceptable carrier. The present invention provides method of administering these vaccines to treat, prevent or delay the onset of cancer.
A composition comprising:
A composition comprising a modified cancer cell with reduced lipid content as compared to an unmodified cancer cell of the same cancer type and at least one cancer cell antigen.
A composition comprising a modified cancer cell with reduced lipid content, as compared to an unmodified cancer cell of the same cancer type, and at least one cancer cell antigen, wherein the reduced lipid content in the modified cancer cell is reduced by at least 20% as compared to the unmodified cancer cell.
A method for reducing levels of lipid in a cancer cell comprising:
A method for delipidation of cancer cells comprising:
Dependencies are inferred from the claim text.