Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
AssigneeViralytics Limited
InventorDarren R. Shafren
Life of this patent
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Abstract
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
Claims22
A method for treating cancer cells expressing the cell adhesion molecule ICAM-1 in a mammal, comprising administering to the mammal an effective amount of a coxsackie virus A (CVA) selected from the group consisting of CVA13, CVA15, CVA18 and CVA21 that recognizes ICAM-1 wherein at least one of the cancer cells are killed by the CVA.
A method for treating melanoma in a mammal, comprising administering to the mammal an effective amount of a coxsackie A group virus (CVA) is selected from the group consisting of or CVA13, or CVA15, or CVA18 and or CVA21 that recognizes the cell adhesion molecule ICAM-1, such that at least some melanoma cells in the mammal are killed by the CVA.
A method for treating prostate cancer cells expressing the cell adhesion molecule ICAM-1 in a mammal, comprising administering to the mammal an effective amount of a coxsackie A group virus selected from the group consisting of CAV13, CAV15, CAV18 and CAV21 that recognizes the cell adhesion molecule ICAM-1, such that at least some prostate cancer cells in the mammal are killed by the virus.
A method for treating breast cancer cells expressing the cell adhesion molecule ICAM-1 in a mammal, comprising administering to the mammal an effective amount of a coxsackie A group virus selected from the group consisting of CAV13, CAV15, CAV18 and CAV21 that recognizes the cell adhesion molecule ICAM-1, such that at least some breast cancer cells in the mammal are killed by the virus.
Dependencies are inferred from the claim text.