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US 7,358,400 B2Granted
Process for producing cyclopropane monoacetal derivative and intermediate therefor
AssigneesKuraray Co., Ltd., Daiichi Pharmaceutical Co., Ltd.
InventorsKenichi Koyakumaru, Shingo Ueyama, Katsuji Ujita, Tatsuhiko Hayashibara, Naoshi Nakagawa, Toshifumi Akiba, Tatsuru Saito
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Abstract
A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.
Claims6
A method of producing a cyclopropane monoacetal derivative represented by the formula (III)
- wherein R1, R2, R3, R4, R5 and R6 each independently represents a hydrogen atom, a saturated hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s), an alkenyl group or an aralkyl group, R8 represents a saturated hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s) or an aralkyl group, and R9 represents a saturated hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s) or an aralkyl group, which comprises reacting a halogenated unsaturated carbonyl compound represented by the formula (II)
- wherein R1, R2, R3, R4, R5, R6 and R8 represent as defined above, and X represents a halogen atom, with an alcoholate.
A halogenated unsaturated carbonyl compound represented by the formula (II):
- wherein R1, R2, R3, R4, R5 and R6 each independently represents a hydrogen atom, a saturated hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s), an alkenyl group or an aralkyl group, R8 represents a saturated hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s) or an aralkyl group, and X represents a halogen atom.
Dependencies are inferred from the claim text.