Ultrasonic concentration of drug delivery capsules
AssigneeThe Regents of the University of California
InventorsPaul Dayton, Katherine W. Ferrara, Michaelann Shortencarier, Susannah Bloch
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Abstract
Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation is used to fragment the localized carriers, releasing associate compounds. Ultrasound radiation is preferred as the source for radiation force and for fragmentation. Also encompassed are embodiments in which targeting and fragmentations are combined with imaging of the treatment site. Alternate embodiments are disclosed in which compounds are locally delivered without use of carriers.
Claims51
A method for localized delivery of a compound, comprising:
- administering a carrier, said carrier comprising a therapeutic compound, wherein the carrier is selected from the group consisting of an acoustically active liposphere and a gas-filled agent;
- concentrating said carrier by exposing said carrier to an ultrasound radiation force generated by an ultrasound wave at a first frequency and pressure combination, thereby locally delivering said therapeutic compound, wherein said ultrasound wave at said first frequency and pressure combination concentrates and displaces said administered carrier, but does not rupture said carrier;
- and
- rupturing said concentrated carrier by insonating said concentrated carrier with an ultrasound wave at a second frequency and pressure combination.
A method for localized delivery of a compound, comprising:
- administering a carrier, said carrier comprising a therapeutic compound, wherein the carrier is selected from the group consisting of an acoustically active liposphere and gas-filled agent;
- and
- concentrating said carrier by exposing said carrier to an ultrasound radiation force generated by an ultrasound wave at a first frequency and pressure combination, thereby locally delivering said therapeutic compound, wherein said ultrasound wave at said first frequency and pressure combination concentrates but does not rupture said carrier;
- wherein said carrier comprises a polymer, a protein, a lipid, an oil, or a gas and a shell having a thickness>50 nm.
A method for localized delivery of a compound, comprising:
- administering a carrier, said carrier comprising a therapeutic compound, wherein said carrier is selected from the group consisting of an acoustically active liposphere and a gas-filled agent, wherein said administration is into a vessel;
- and
- concentrating said carrier by exposing said carrier to an ultrasound radiation force generated by an ultrasound wave at a first frequency and pressure combination, thereby locally delivering said therapeutic compound, wherein said ultrasound wave at said first frequency and pressure combination concentrates but does not rupture said carrier;
- wherein said concentration is achieved by a mechanism selected from the group consisting of the ultrasound radiation force reducing a flow velocity of said administered carrier, and the ultrasound radiation force displacing said administered carrier to a wall of said vessel;
- and
- rupturing said concentrated carder by insonating said concentrated carder with an ultrasound wave at a second frequency and pressure combination.
Dependencies are inferred from the claim text.