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US 7,358,062 B2Granted
Method for diagnosing atrophic gastritis
AssigneeBiohit Oyj
InventorsOsmo Suovaniemi, Matti Härkönen, Tapani Tiusanen, Pentti Sipponen
Life of this patent
Estimating the term…
Abstract
The press device for a paper web, such as a calender, contains a flexible moving element (1a) forming an endless structure, said element forming the shell (1) of a roll, the press device including further a counter roll. Inside the moving element (1a) there is a shoe element (3) that is arranged to support the shell (1a) against the counter roll to form a nip (N). The width and/or the surface contour of the supporting surface of the shoe element (3) guiding the shell of the roll in the nip contact varies in the machine direction and the shoe element is positionable in the machine direction to adjust the nip width and/or length.
Claims26
A method for assessing the condition of the gastric mucosa in a subject to diagnose gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum gastritis, atrophic antrum/corpus gastritis and non-atrophic gastritis by assaying (i) pepsinogen I (PGI), (ii) unstimulated gastrin-17 (G17) or stimulated gastrin 17 (stG17) and (iii) a marker for Helicobacter pylon infection (Hp-Marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample from step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (4) determining
- a value for said Hp-marker by quantitatively measuring the enzyme immunoassay units (EIU) value of an Helicobacter pylori (Hp) antibody in said sample from step (1);, and
- (5) entering into a data processing system comprising a data storing means or a data display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high G17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result,
- (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an antibody HP-marker comparison result, and
- (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa condition of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Normal
- <20-30 μg/l
- ≧10 pmol/l stG17 or
- ≦30 EIU
- Atrophic corpus
- ≧5 pmol/l G17
- gastritis
- <20-30 μg/l
- <10 pmol/l stG17 or
- ≦30 EIU
- Atrophic antrum/
- <5 pmol/l G17
- corpus gastritis
- <20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Atrophic antrum/
- <2.5 pmol/l G17
- corpus gastritis
- ≧20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Atrophic antrum
- <2.5 pmol/l G17
- gastritis
- <50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Atrophic antrum
- 2.5-5 pmol/l G17
- gastritis
- ≧50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Non-atrophic
- 2.5-5 pmol/l G17
- gastritis
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Non-atrophic
- >5 pmol/l G17
- gastritis
- <20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Atrophic corpus
- >5 pmol/l G17
- gastritis
- and stores or displays said diagnosis information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject a normal gastric mucosa condition or one or more gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum/corpus gastritis, atrophic antrum gastritis and non-atrophic gastritis.
65 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum gastritis, atrophic antrum/corpus gastritis and non-atrophic gastritis by assaying (i) pepsinogen I (PGI), (ii) unstimulated gastrin-17 (G17) or stimulated gastrin 17 (stG17) and (iii) a marker for Helicobacter pylori infection (Hp-Marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) obtaining a stool, breath or biopsy sample from said subject;
- (3) quantitatively measuring the concentration of PGI in said sample from step (1);
- (4) quantitatively measuring the concentration of G17 or stG17 in said sample from said step (1);
- (5) determining the presence or absence of an Hp antigen in said sample obtained from said subject in step (2), and
- (6) entering into a data processing system comprising a data storing means or a data display the PGI concentration, the G17 or stG17 concentration and the presence or absence of the Hp antigen, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high G17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result , and
- (c) combining the comparison results of steps 6(a), 6(b) and the presence or absence of the HP marker to generate diagnosis information for the gastric mucosa condition of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30
- Any
- Absent
- Normal
- μg/l
- <20-30
- ≧10 pmol/l stG17
- Absent
- Atrophic corpus gastritis
- μg/l
- or ≧5 pmol/l G17
- <20-30
- <10 pmol/l stG17
- Absent
- Atrophic antrum/corpus
- μg/l
- or <5 pmol/l G17
- gastritis
- <20-30
- <5 pmol/l stG17 or
- Present
- Atrophic antrum/corpus
- μg/l
- <2.5 pmol/l G17
- gastritis
- ≧20-30
- <5 pmol/l stG17 or
- Present
- Atrophic antrum gastritis
- μg/l
- <2.5 pmol/l G17
- <50 μg/l
- 5-10 pmol/l stG17
- Present
- Atrophic antrum gastritis
- or 2.5-5 pmol/l
- G17
- ≧50 μg/l
- 5-10 pmol/l stG17
- Present
- Non-atrophic gastritis
- or 2.5-5 pmol/l
- G17
- >20-30
- >10 pmol/l stG17
- Present
- Non-atrophic gastritis
- μg/l
- or >5 pmol/l G17
- <20-30
- >10 pmol/l stG17
- Present
- Atrophic corpus gastritis
- μg/l
- or >5 pmol/l G17
- (7) using said stored or displayed diagnosis information to diagnose in said subject a normal gastric mucosa condition or one or more gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum/corpus gastritis, atrophic antrum gastritis and non-atrophic gastritis.
66 more elements
A computer readable storage medium comprising computer code which when executed on a computer assesses the condition of the gastric mucosa in a patient by performing the steps comprising:
- (a) comparing a quantitatively measured Pepsinogen I (PGI) concentration value to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a comparison result;
- (b) comparing a quantitatively measured G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing a quantitatively measured stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high G17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result;
- (c) comparing a quantitatively measured Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an Hp antibody comparison result or assessing an entered Hp antigen status as positive or negative, and
- (d) combining the comparison results of steps (a), (b) and (c) or combining the comparison results of steps (a) and (b) and the antigen Hp-marker positive or negative status to generate diagnosis information for the gastric mucosa condition of said subject according to the following table:
- HP-Marker
- PGI
- G17 or stG17
- Antibody
- Antigen
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Negative
- Normal
- <20-30 μg/l
- ≧10 pmol/l stG17 or
- ≦30 EIU
- Negative
- Atrophic corpus gastritis
- ≧5 pmol/l G17
- <20-30 μg/l
- <10 pmol/l stG17 or
- ≦30 EIU
- Negative
- Atrophic antrum/corpus gastritis
- <5 pmol/l G17
- <20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Positive
- Atrophic antrum/corpus gastritis
- <2.5 pmol/l G17
- ≧20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Positive
- Atrophic antrum gastritis
- <2.5 pmol/l G17
- <50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Positive
- Atrophic antrum gastritis
- 2.5-5 pmol/l G17
- ≧50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Positive
- Non-atrophic gastritis
- 2.5-5 pmol/l G17
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Positive
- Non-atrophic gastritis
- >5 pmol/l G17
- <20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Positive
- Atrophic corpus gastritis
- >5 pmol/l G17,
- and
- (e) outputting as a result of said comparing steps diagnosis information for diagnosing a normal gastric mucosa condition or one or more gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum/corpus gastritis, atrophic antrum gastritis and non-atrophic gastritis.
62 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a gastric mucosa condition of atrophic corpus gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample from step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (4) determining
- a value for said Hp-marker by quantitatively measuring the enzyme immunoassay units (EIU) value of an Helicobacter pylori (Hp) antibody in said sample from step (1);
- and
- (5) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result
- (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an Hp antibody comparison result, and
- (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Normal
- <20-30 μg/l
- ≧10 pmol/l stG17 or
- ≦30 EIU
- Atrophic corpus
- ≧5 pmol/l G17
- gastritis
- <20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Atrophic corpus
- >5 pmol/l G17
- gastritis
- and stores or displays said diagnosis information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject the gastric mucosa condition of atrophic corpus gastritis.
30 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a condition of atrophic antrum/corpus gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample from step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (4) determining
- a value for said Hp-marker by quantitatively measuring the enzyme immunoassay units (EIU) value of an Helicobacter pylori (Hp) antibody in said sample from step (1);
- and
- (5) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/1 to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result,
- (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an Hp antibody comparison result, and
- (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Normal
- <20-30 μg/l
- <10 pmol/l stG17 or
- ≦30 EIU
- Atrophic antrum/
- <5 pmol/l G17
- corpus gastritis
- <20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Atrophic antrum/
- <2.5 pmol/l G17
- corpus gastritis
- and stores or displays said diagnosis information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject the condition of atrophic antrum/corpus gastritis.
30 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a condition of atrophic antrum gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample from step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (4) determining
- a value for said Hp-marker by quantitatively measuring the enzyme immunoassay units (EIU) value of an Helicobacter pylori (Hp) antibody in said sample from step (1);
- and
- (5) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result,
- (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an Hp antibody comparison result, and
- (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- Antibody HP-
- PGI
- G17 or stG17
- Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Normal
- ≧20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Atrophic antrum
- <2.5 pmol/l G17
- gastritis
- <50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Atrophic antrum
- 2.5-5 pmol/l G17
- gastritis
- and stores or displays said diagnosis information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject the condition of atrophic antrum gastritis.
31 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a condition of non-atrophic gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample from step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (4) determining
- a value for said Hp-marker by quantitatively measuring the enzyme immunoassay units (EIU) value of an Helicobacter pylori (Hp) antibody in said sample from step (1);
- and
- (5) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result,
- (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an Hp antibody comparison result,
- and
- (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Normal
- ≧50 μg/l
- 5-10 pmol/l stG17
- >30 EIU
- Non-atrophic gastritis
- or 2.5-5 pmol/l G17
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Non-atrophic gastritis
- >5 pmol/l G17
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Non-atrophic gastritis
- >5 pmol/l G17,
- and stores or displays said diagnosis information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject the condition of non-atrophic gastritis.
34 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum gastritis, atrophic antrum/corpus gastritis and non-atrophic gastritis by assaying (i) pepsinogen I (PGI), (ii) unstimulated gastrin-17 (G17) or stimulated gastrin 17 (stG17) and (iii) a marker for Helicobacter pylori infection (Hp-Marker), the method comprising:
- (1) obtaining a sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample from step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (4) determining
- a value for said Hp-marker by quantitatively measuring the enzyme immunoassay units (EIU) value of an Helicobacter pylori (Hp) antibody in said sample;
- and
- (5) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the EIU value of the Hp antibody, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result,
- (c) comparing said Hp antibody value to an Hp antibody cut-off (Hp-co) value of 30 EIU to obtain an antibody HP-marker comparison result, and
- (d) combining the comparison results of steps 5(a), 5(b) and 5(c) to generate diagnosis information for the gastric mucosa condition of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- ≦30 EIU
- Normal
- <20-30 μg/l
- ≧10 pmol/l stG17 or
- ≦30 EIU
- Atrophic corpus
- ≧5 pmol/l G17
- gastritis
- <20-30 μg/l
- <10 pmol/l stG17 or
- ≦30 EIU
- Atrophic antrum/
- <5 pmol/l G17
- corpus gastritis
- <20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Atrophic antrum/
- <2.5 pmol/l G17
- corpus gastritis
- ≧20-30 μg/l
- <5 pmol/l stG17 or
- >30 EIU
- Atrophic antrum
- <2.5 pmol/l G17
- gastritis
- <50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Atrophic antrum
- 2.5-5 pmol/l G17
- gastritis
- ≧50 μg/l
- 5-10 pmol/l stG17 or
- >30 EIU
- Non-atrophic
- 2.5-5 pmol/l G17
- gastritis
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Non-atrophic
- >5 pmol/l G17
- gastritis
- <20-30 μg/l
- >10 pmol/l stG17 or
- >30 EIU
- Atrophic corpus
- >5 pmol/l G17
- gastritis
- and stores or displays said diagnostic information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject a normal gastric mucosa condition or one or more gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum/corpus gastritis, atrophic antrum gastritis and non-atrophic gastritis.
66 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a gastric mucosa condition of atrophic corpus gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) obtaining a stool, breath or biopsy sample from said subject;
- (3) quantitatively measuring the concentration of PGI in said sample from step (1);
- (4) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (5) determining the presence or absence of an Hp antigen in a stool, breath or biopsy in said sample from step (2), and
- (6) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the presence or absence of the Hp antigen, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result, and
- (c) combining the comparison results of steps 6(a), 6(b) and the presence or absence of the HP marker to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30
- Any
- Absent
- Normal
- μg/l
- <20-30
- ≧10 pmol/l stG17
- Absent
- Atrophic corpus gastritis
- μg/l
- or ≧5 pmol/l G17
- <20-30
- >10 pmol/l stG17
- Present
- Atrophic corpus gastritis
- μg/l
- or >5 pmol/l G17
- and stores or displays said diagnosis information, and
- (7) using said stored or displayed diagnosis information to diagnose in said subject the gastric mucosa condition of atrophic corpus gastritis.
29 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a condition of atrophic antrum/corpus gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) obtaining a stool, breath or biopsy sample from said subject;
- (3) quantitatively measuring the concentration of PGI in said sample from step (1);
- (4) quantitatively measuring the concentration of G17 or stG17 in said sample from step (1);
- (5) determining the presence or absence of an Hp antigen in said sample from step (2), and
- (6) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the presence or absence of the Hp antigen, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result, and
- (c) combining the comparison results of steps 6(a), 6(b) and the presence or absence of the Hp antigen to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30
- Any
- Absent
- Normal
- μg/l
- <20-30
- <10 pmol/l stG17
- Absent
- Atrophic antrum/corpus
- μg/l
- or <5 pmol/l G17
- gastritis
- <20-30
- <5 pmol/l stG17
- Present
- Atrophic antrum/corpus
- μg/l
- or <2.5 pmol/l
- gastritis
- G17
- and stores or displays said diagnosis information, and
- (7) using said stored or displayed diagnosis information to diagnose in said subject the condition of atrophic antrum/corpus gastritis.
32 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a condition of atrophic antrum gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) obtaining a stool, breath or biopsy sample from said subject;
- (3) quantitatively measuring the concentration of PGI in said sample obtained from said subject in step (1);
- (4) quantitatively measuring the concentration of G17 or stG17 in said sample obtained from said subject in step (1);
- (5) determining the presence or absence of an Hp antigen in said sample from step (2), and
- (6) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and either the EIU value of the Hp antibody or the Hp antigen status as Boolean parameter, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result, and
- (c) combining the comparison results of steps 6(a), 6(b) and the presence or absence of said Hp antigen to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- Absent
- Normal
- ≧20-30 μg/l
- <5 pmol/l stG17 or
- Present
- Atrophic antrum
- <2.5 pmol/l G17
- gastritis
- <50 μg/l
- 5-10 pmol/l stG17 or
- Present
- Atrophic antrum
- 2.5-5 pmol/l G17
- gastritis
- and stores or displays said diagnosis information, and
- (7) using said stored or displayed diagnosis information to diagnose in said subject the condition of atrophic antrum gastritis.
28 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose a condition of non-atrophic gastritis by assaying pepsinogen I (PGI), unstimulated gastrin-17(G17) or stimulated gastrin-17 (stG17) and a marker for Helicobacter pylori infection (Hp-marker), the method comprising:
- (1) obtaining a serum, urine, saliva or lacrimal fluid sample from said subject;
- (2) obtaining a stool, breath or biopsy sample from said subject;
- (3) quantitatively measuring the concentration of PGI in said sample obtained from said subject in step (1);
- (4) quantitatively measuring the concentration of G17 or stG17 in said sample obtained from said subject in step (1);
- (5) determining the presence or absence of an Hp antigen in said sample from step (2);
- and
- (6) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and the presence or absence of said Hp antigen, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-coI) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result, and
- (c) combining the comparison results of steps 6(a), 6(b) and the presence or absence of said Hp antigen to generate diagnosis information for the gastric mucosa of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30 μg/l
- Any
- Absent
- Normal
- ≧50 μg/l
- 5-10 pmol/l stG17
- Present
- Non-atrophic gastritis
- or 2.5-5 pmol/l G17
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- Present
- Non-atrophic gastritis
- >5 pmol/l G17
- ≧20-30 μg/l
- >10 pmol/l stG17 or
- Present
- Non-atrophic gastritis
- >5 pmol/l G17,
- and stores or displays said diagnosis information, and
- (7) using said stored or displayed diagnosis information to diagnose in said subject the condition of non-atrophic gastritis.
32 more elements
A method for assessing the condition of the gastric mucosa in a subject to diagnose gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum gastritis, atrophic antrum/corpus gastritis and non-atrophic gastritis by assaying (i) pepsinogen I (PGI), (ii) unstimulated gastrin-17 (G17) or stimulated gastrin 17 (stG17) and (iii) a marker for Helicobater pylori infection (Hp-Marker), the method comprising:
- (1) obtaining a sample from said subject;
- (2) quantitatively measuring the concentration of PGI in said sample obtained from said subject in step (1);
- (3) quantitatively measuring the concentration of G17 or stG17 in said sample obtained from said subject in step (1);
- (4) determining the presence or absence of an Hp antigen in said sample, and (5) entering into a data processing system comprising a data storing means or a display the PGI concentration, the G17 or stG17 concentration and either the EIU value of the Hp antibody or the presence or absence of said Hp antigen, wherein said data processing system comprises computer code which, when executed on a computer, performs the steps comprising:
- (a) comparing said PGI concentration to a low PGI cut-off value (PGI-coI) of 20-30 μg/l and a high PGI cut-off value (PGI-coII) of 50 μg/l to obtain a PGI comparison result,
- (b) comparing said G17 concentration to a low G17 cut-off value (G17-coI) of 2.5 pmol/l and a high G17 cut-off value (G17-coII) of 5 pmol/l to obtain a G17 comparison result or comparing said stG17 concentration to a low stG17 cut-off value (stG17-co I) of 5 pmol/l and a high stG17 cut-off value (stG17-coII) of 10 pmol/l to obtain a stG17 comparison result ,and
- (c) combining the comparison results of steps 5(a), 5(b) and the presence or absence of said antigen Hp-marker to generate diagnosis information for the gastric mucosa condition of said subject according to the following table:
- PGI
- G17 or stG17
- HP-Marker
- Diagnosis
- ≧20-30
- Any
- Absent
- Normal
- μg/l
- <20-30
- ≧10 pmol/l stG17
- Absent
- Atrophic corpus gastritis
- μg/l
- or ≧5 pmol/l G17
- <20-30
- <10 pmol/l stG17
- Absent
- Atrophic antrum/corpus
- μg/l
- or <5 pmol/l G17
- gastritis
- <20-30
- <5 pmol/l stG17 or
- Present
- Atrophic antrum/corpus
- μg/l
- <2.5 pmol/l G17
- gastritis
- ≧20-30
- <5 pmol/l stG17 or
- Present
- Atrophic antrum gastritis
- μg/l
- <2.5 pmol/l G17
- <50 μg/l
- 5-10 pmol/l stG17
- Present
- Atrophic antrum gastritis
- or 2.5-5 pmol/l
- G17
- ≧50 μg/l
- 5-10 pmol/l stG17
- Present
- Non-atrophic gastritis
- or 2.5-5 pmol/l
- G17
- ≧20-30
- >10 pmol/l stG17
- Present
- Non-atrophic gastritis
- μg/l
- or >5 pmol/L G17
- <20-30
- >10 pmol/l stG17
- Present
- Atrophic corpus gastritis
- μg/l
- or >5 pmol/l G17
- and stores or displays said diagnostic information, and
- (6) using said stored or displayed diagnosis information to diagnose in said subject a normal gastric mucosa condition or one or more gastric mucosa conditions selected from the group consisting of atrophic corpus gastritis, atrophic antrum/corpus gastritis, atrophic antrum gastritis and non-atrophic gastritis.
65 more elements
Dependencies are inferred from the claim text.