Adjuvant systems and vaccines
AssigneeSmithKline Beecham Biologicals s.a.
InventorNathalie Garcon
Life of this patent
Estimating the term…
Abstract
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting particle is essentially devoid of antigen.
Claims52
A process for the manufacture of a vaccine composition comprising admixing a) an adjuvant composition containing an immunostimulant adsorbed onto a first metallic salt particle substantially free of antigen, and b) an antigen, wherein the antigen is adsorbed onto a second metallic salt particle substantially free of immunostimulant, wherein the metallic salt of each of the first metallic salt particle and the second metallic salt particle may be the same.
A process for the manufacture of an immunogenic composition comprising admixing a) an adjuvant composition containing an immunostimulant adsorbed onto a first metallic salt particle substantially free of antigen, and b) an antigen, wherein the antigen is adsorbed onto a second metallic salt particle substantially free of immunostimulant wherein the metallic salt of each of the first metallic salt particle and the second metallic salt particle may be the same and wherein the antigen of b) elicits an immune response to a pathogen, polypeptide, or anti-tumour antigen selected from the group consisting of antigens derived from Human Immunodeficiency Virus, Varicella Zoster virus, Herpes Simplex Virus type 1, Herpes Simplex Virus type 2, Human cytomegalovirus, Dengue virus, Hepatitis A, B, C or E, Respiratory Syncytial virus, human papilloma virus, Influenza virus, Haemophilus influenzae Type B (“Hib”), Meningitis virus, Salmonella, Neisseria, Borrelia, Chlamydia, Bordetella, Plasmodium or Toxoplasma, IgE peptides, Der p1, pollen related antigens;
- or Tumor associated antigens (TAA), MAGE, BAGE, GAGE, MUC-1, Her-2 neu, luteinizing hormone-releasing hormone (gonadotropin-releasing hormone), CEA, PSA, KSA, and PRAME.
A vaccine composition comprising an adjuvant composition and an antigen, wherein the adjuvant composition contains an immunostimulant adsorbed onto a metallic salt particle, wherein the metallic salt particle is substantially free of the antigen and wherein the immunostimulant is selected from the group consisting of monophosphoryl lipid A, derivatives thereof, an immunostimulatory nucleotide, and an immunostimulatory cytokine.
A vaccine composition comprising two major populations of complexes, (a) a first complex containing an immunostimulant adsorbed onto a metallic salt particle which is substantially free of antigen;
- and (b) a second complex containing antigen adsorbed onto a metallic salt particle which is optionally substantially free of immunostimulant;
- wherein the metallic salt from the first complex may be identical to or different from the metallic salt of the second complex.
A vaccine composition comprising:
- a) an immunostimulant adsorbed onto a metallic salt particle, wherein the immunostimulant is selected from the group consisting of bacterially derived compounds, monophosphoryl lipid A, immunostimulatory oligonucleotides, CpG, block copolymers, cholera toxin, immunostimulatory cytokines, GM-CSF, IL-1, polyriboA, polyriboU, and Muramyl tripeptide, and b) an antigen, wherein the antigen is not adsorbed onto the metallic salt particle.
An immunogenic composition comprising an adjuvant composition and an antigen, wherein the adjuvant composition contains an immunostimulant adsorbed onto a metallic salt particle, wherein the metallic salt particle is substantially free of the antigen and wherein the immunostimulant is selected from the group consisting of monophosphoryl lipid A, derivatives thereof, an immunostimulatory nucleotide, and an immunostimulatory cytokine.
An immunogenic composition comprising two populations of complexes, a first complex comprising, (a) a first complex containing an immunostimulant adsorbed onto a metallic salt particle, which is substantially free of antigen;
- and (b) a second complex containing antigen adsorbed onto a metallic salt particle which is optionally substantially free of immunostimulant;
- wherein the metallic salt from the first complex may be identical to or different from the metallic salt of the second complex.
Dependencies are inferred from the claim text.