Expression of protective antigens in transgenic chloroplasts
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorHenry Daniell
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Abstract
Vectors and methods for plastid transformation of plants to produce protective antigens and vaccines for oral delivery are provided. The invention provides edible vaccines for conferring immunity to a mammal against Bacillus anthracis, as well as Yersina pestis.
Claims2
A plastid transformation vector for stably transforming a plastid, said plastid vector comprising, as operably linked components, a first flanking sequence, at least one regulatory sequence operable in a plastid, a DNA sequence coding for a protective antigen, a DNA sequence coding for a chaperonin, and a second flanking sequence.
A plastid transformation vector for stably transforming a plastid, said plastid vector comprising, as operably linked components, a first flanking sequence, at least one regulatory sequence operable in a plaslid, a DNA sequence coding for a protective antigen, a DNA sequence coding for a chaperonin, and a second flanking sequence, wherein said protective antigen is a bacterial antigen.
Dependencies are inferred from the claim text.