Methods of using substituted tetralins and indanes

A compound of Formula I

• or a pharmaceutically acceptable salt, C1-6 ester or C1-6 amide thereof, wherein
• each of R1 and R2 is independently H, C1-6 alkyl, (CH2)mNRaRb, (CH2)mOR8, (CH2)mNH(CO)R8, or (CH2)mCO2R8, where each of Ra, Rb, and R8 is independently H or C1-6 alkyl, or R1 and R2 taken together with the carbon atom to which they are attached are a C3-7 cycloalkyl;
• m is between 1 and 6;
• n is 1 or 2;
• X is O or S;
• wherein X is at the 5 or 6 position when n is 1;
• and wherein X is at the 6 or 7 position when n is 2;
• R3 is H, phenyl, C1-3 alkoxy, C1-3 alkylthio, halo, cyano, C1-6 alkyl, nitro, NR9R10, NHCOR10, CONHR10;
• and COOR10;
• and R3 is ortho or meta to X;
• R4 is H or —(C1-5 alkylene)R15, where R15 is H, C1-7 alkyl, [di(C1-2 alkyl)amino](C1-6 alkylene), (C1-3 alkoxyacyl)(C1-6 alkylene), C1-6 alkoxy, C3-7 alkenyl, or C3-8 alkynyl, wherein R4 has no more than 9 carbon atoms;
• R4 can also be —(C1-5 alkylene)R15 wherein R15 is C3-6 cycloalkyl, phenyl, phenyl-O—, phenyl-S—, or a 5-6 membered heterocyclyl with between 1 and 2 heteroatoms selected from N, O, and S;
• Y is NH, NH—CH2, and O;
• each of R5 and R7 is independently selected from H, C1-6 alkyl, halo, cyano, nitro, COR11, COOR11, C1-4 alkoxy, C1-4 alkylthio, hydroxy, phenyl, NR11R12 and 5-6 membered heterocyclyl with between 1 and 2 heteroatoms selected from N, O, and S;
• R6 is selected from C1-6 alkyl, halo, cyano, nitro, COR13, COOR13, C1-4 alkoxy, C1-4 alkylthio, hydroxy, phenyl, NR13R14 and 5-6 membered heterocyclyl with between 1 and 2 heteroatoms selected from N, O, and S;
• in addition, either R5 and R6 or R6 and R7 may be taken together to be a bivalent moiety, saturated or unsaturated, selected from —(CH2)3—, —(CH2)4—, and (CH1-2)pN(CH1-2)q,
• p is 0-2 and q is 1-3, where the sum (p+q) is at least 2;
• each of R9 and R10 is independently C1-6 alkyl;
• each of R11, R12, R13 and R14 is independently H or C1-6 alkyl;
• wherein each of the above hydrocarbyl and heterocarbyl moieties may be substituted with between 1 and 3 substituents independently selected from F, Cl, Br, I, amino, methyl, ethyl, hydroxy, nitro, cyano, and methoxy.