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US 7,351,854 B2Granted
Method of manufacturing 1-chloro-2-methyl-4-acyloxy-2-butene derivatives
AssigneesShaoxing University, Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
InventorsRunpu Shen, Guoqi Yu, Weidong Ye, Kui Wang, Xuejun Lao
Life of this patent
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Abstract
1-Chloro-2-methyl-4-acyloxy-2-butene derivatives can be synthesized in good yields and high purity starting from isoprene and employing a chlorohydrin formation reaction in a system made of N-chloroisocyanuric acid derivatives and water, followed by esterification and rearrangement of the crude product mixture.
Claims14
A method of manufacturing a 1-chloro-2-methyl-4-acyloxy-2-butene derivative having the following structure:
- wherein R1 is an alkyl,
- comprising
- (1) reacting isoprene with at least one N-chloroisocyanuric acid derivative and water to obtain a mixture of 1-chloro-2-hydroxy-2-methyl-3-butylene and 1-chloro-4-hydroxy-2-methyl-2-butylene;
- (2) reacting the mixture obtained in step (1) under acidic conditions with an acid anhydride or an acyl halide to undergo esterification and rearrangement to yield the 1-chloro-2-methyl-4-acyloxy-2-butene derivative having the following structure:
- wherein R1 is an alkyl.
2 more elements
Dependencies are inferred from the claim text.