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US 7,351,842 B2Granted
Compounds for treatment of cardiac arrhythmia and methods of use
AssigneeARYx Therapeutics, Inc.
InventorPascal Druzgala
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Abstract
The subject invention provides novel compounds for treatment of cardiac arrhythmia and methods of use.
Claims42
A pharmaceutically acceptable salt of a compound of structural Formula II:
- wherein
- R1 is H or C1-C10 alkyl;
- R2 is H or optionally substituted C1-C10 alkyl, heteroalkyl, cycloalkyl or heterocycloalkyl;
- n=0 to 4;
- p=0 or 1;
- R3 and R4 are, independently, H or C1-C4 alkyl, and wherein the salt is selected from hydrochloride, hydrobromide, p-toluenesulfonate, phosphate, sulfate, perchlorate, acetate, trifluororacetate, propionate, citrate, malonate, succinate, lactate, oxalate, (L)-tartrate, (D)-tartrate, meso-tartrate, benzoate, alkali metal, morpholine, piperidine, dimethylamine, and diethylamine salts.
3 more elements
A compound of structural Formula II:
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is H or C1-C10 alkyl;
- R2 is H or optionally substituted C1-C10 alkyl, heteroalkyl, cycloalkyl or heterocycloalkyl;
- n=0 to 4;
- p=0 or 1;
- R3 and R4 are, independently, H or C1-C4 alkyl;
- and wherein a compound contains less than 20% impurities on a weight basis.
4 more elements
Dependencies are inferred from the claim text.