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US 7,351,835 B2Granted
Organic molecular cataylst having binaphthol skeleton and processes for producing the same and application thereof
AssigneeMeiji Seika Kaisha, Ltd.
InventorsHiroaki Sasai, Shinobu Takizawa, Katsuya Matsui
Life of this patent
Estimating the term…
Abstract
A novel organic molecular catalysts represented by the following formula (1) or (2): and a method for carrying out asymmetric reactions/asymmetric synthesis using these organic molecular catalysts.
Claims4
A compound represented by formula (III) or (IV):
- wherein n represents an integer of from 1 to 6, R2 represents a hydrogen atom, a linear or branched alkyl group having from 1 to 6 carbon atoms, a linear or branched alkenyl group having from 2 to 6 carbon atoms, or an aralkyl group having 7 or 8 carbon atoms, R3 represents a 2-pyridyl group which may be substituted by a lower alkyl group or a halogen atom, a 3-pyridyl group which may be substituted by a lower alkyl group or a halogen atom, or a 4-pyridyl group which may be substituted by a lower alkyl group or a halogen atom, or a salt thereof.
A process for producing a compound of formula (XIII) or (XIV):
- wherein R2 represents a hydrogen atom, a linear or branched alkyl group having from 1 to 6 carbon atoms, a linear or branched alkenyl group having from 2 to 6 carbon atoms, or an aralkyl group having 7 or 8 carbon atoms, R3 represents a 2-pyridyl group which may be substituted by a lower alkyl group or a halogen atom, a 3-pyridyl group which may be substituted by a lower alkyl group or a halogen atom, or a 4-pyridyl group which may be substituted by a lower alkyl group or a halogen atom;
- wherein the process comprises (a) reacting, in the presence of a base, a compound of formula (XI) or (XII):
- wherein MOM represents a protective group, with a (2-, 3-, or 4-)R2NH-pyridine wherein R2 has the same meanings as above, and (b) removing the protective groups on the protected binaphthol compound obtained in (a).
Dependencies are inferred from the claim text.