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US 7,351,815 B2Granted
Canine pre-proGHRH and mature GHRH genes
AssigneeMerial Limited
InventorsLaurent Bernard Fisher, Nathalie Michele Cachet, Simona Barzu-Le Roux
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Abstract
The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-proGHRH or the canine GHRH which can be used to treat disease and growth hormone deficiencies by gene therapy in vertebrates, in particular in dogs.
Claims19
An isolated DNA molecule:
- (a) encoding a canine pre-proGHRH polypeptide having at least 90% sequence identity to SEQ ID NO:
- 1;
- or
- (b) having at least 90% sequence identity to SEQ ID NO:
- 3 and encoding a canine pre-proGHRH;
- wherein the canine pre-proGHRH polypeptide, when expressed in vivo in a canine is able to be cellularly processed to mature, canine GHRH with the ability to stimulate Growth Hormone secretion.
3 more elements
An isolated DNA molecule:
- (a) encoding a canine mature GHRH polypeptide having at least 93% sequence identity to SEQ ID NO:
- 4;
- or
- (b) having at least 97% sequence identity to SEQ ID NO:2 and encoding a canine mature GHRH;
- wherein the canine mature GHRH polypeptide, when expressed in vivo in a canine is a canine GHRH with the ability to stimulate Growth Hormone secretion.
2 more elements
Dependencies are inferred from the claim text.