Back to results
US 7,351,800 B2Granted
Stabilized albumin preparations
AssigneeNipro Corporation
InventorsMasaki Otagiri, Toshiya Kai, Makoto Sato
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeNipro Corporation
InventorsMasaki Otagiri, Toshiya Kai, Makoto Sato
Estimating the term…
This invention provides albumin preparations with safety and without any risk of side effects, which are free from viruses or contaminating proteins and can be stably stored over a long time while showing neither changes in appearance nor decrease in content. There are provided a stabilized albumin preparation produced by uniformly mixing a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative thereof with an aqueous albumin solution (e.g., a buffer such as phosphate buffer which can be administered as pharmaceutical preparations, injection water, or a physiological saline) and dissolving them therein, and then processing the mixture solution into a formulation suitable for parenteral administration such as an intravenous fluid preparation or an injectable solution, and a stabilization method for an albumin preparation.
An albumin preparation, characterized by comprising a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative thereof selected from the group consisting of cystine, methionine, N-acylated cysteine, N-acylated cystine and N-acylated methionine
A stabilization method for an albumin preparation, characterized by comprising blending a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative thereof selected from the group consisting of cystine, methionine, N-acylated cysteine, N-acylated cystine and N-acylated methionine
A stabilized protein preparation for administration to humans and other mammals comprising a protein which is albumin, a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative of a sulfur-containing amino acid selected from the group consisting of N-acylated cysteine, N-acylated cystine and N-acylated methionine
A stabilizer for a protein preparation for administration to humans and other mammals, where the protein is albumin, which comprises a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative of a sulfur-containing amino acid selected from the group consisting of N-acylated cysteine, N-acylated cystine and N-acylated methionine
Dependencies are inferred from the claim text.