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AssigneeThe Scripps Research Institute
InventorsKlaus M. Hahn, Steven J. Bark
Estimating the term…
The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to provide a peptide conjugate having altered biological, chemical, or physical properties. For example, functional molecules (e.g. biophysical probes, peptides, polynucleotides, and therapeutic agents) can be linked to a peptide to provide a peptide conjugate having differing and useful properties. The invention also provides a compound of formula (III): wherein: R6 is a peptide; X is a direct bond or a linking group; R7 is hydrogen, (C1-C6)alkyl, an amino protecting group, or a radical comprising one or more aminooxy groups; Y is a direct bond or a linking group; and D is a functional molecule.
A peptide conjugate of formula (III):
A peptide conjugate of formula (IV):
An isolated peptide consisting essentially of a backbone and one or more protected secondary aminooxy groups, wherein the protected aminooxy group is on an amino acid side chain, the protected aminooxy group is protected with an amino protecting group and is unreactive during Boc solid-phase peptide synthesis, and a substituent on the aminooxy group is (C1-C6)alkyl;
A method for preparing a peptide conjugate comprising reacting a peptide of the formula (VI)
Dependencies are inferred from the claim text.