Process for the preparation of activated polyethylene glycols
AssigneeBioartificial Gel Technologies Inc.
InventorsMarie-Pierre Faure, Kirill Shingel
Life of this patent
Estimating the term…
Abstract
A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the absence of a solvent. The process may be carried out in an inert gas atmosphere, at a temperature at least 10° C. above the melting point of polyethylene glycol, and/or with the activator provided in molar excess of the polyethylene glycol. The invention further provides activated polyethylene glycols produced by this process and their use in a variety of pharmaceutical, medical, cosmetic and chemical applications.
Claims20
A method for preparing an activated polyethylene glycol having the formula:
- Y-Q-(OCH2CH2)n—O-Q-Y
- wherein:
- Q is C(O);
- Y is a leaving group;
- and
- n is an integer greater than 2;
- the method comprising:
- providing a polyethylene glycol having the formula:
- M-(OCH2CH2)n—O-M
- wherein:
- M is selected from H, Li, Na, K, Rb, and Cs;
- and
- n is as defined above;
- and
- reacting in the absence of a solvent the polyethylene glycol with an activator having the formula:
- Y-Q-X
- wherein:
- X is a leaving group;
- and
- Q and Y are as defined above;
- wherein the reaction is carried out in the absence of a base.
A method for preparing an activated polyethylene glycol having the formula:
- Y-Q-(OCH2CH2)n—O-Q-Y
- wherein:
- Q is —C(O)—;
- Y is a leaving group;
- and
- n is an integer greater than 2;
- the method comprising:
- providing a polyethylene glycol having the formula:
- M-(OCH2CH2)n—O-M
- wherein:
- M is selected from H, Li, Na, K, Rb, and Cs;
- and
- n is as defined above;
- and
- reacting in the absence of a solvent the polyethylene glycol with an activator having the formula:
- Y-Q-X
- wherein
- X is a leaving group;
- and
- Q and Y are as defined above;
- wherein the polyethylene glycol is reacted with the activator for less than or about two hours.
A method for preparing an activated polyethylene glycol having the formula:
- Y-Q-(OCH2CH2)n—O-Q-Y
- wherein:
- Q is —C(O)—;
- Y is a leaving group;
- and
- n is an integer greater than 2;
- the method comprising:
- providing a polyethylene glycol having the formula:
- M-(OCH2CH2)n—O-M
- wherein:
- M is selected from H, Li, Na, K, Rb, and Cs;
- and
- n is as defined above;
- reacting in the absence of a solvent the polyethylene glycol with an activator having the formula:
- Y-Q-X
- wherein
- X is a leaving group;
- and
- Q and Y are as defined above;
- and
- contacting the activated polyethylene glycol with ion exchange resins.
Dependencies are inferred from the claim text.