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US 7,351,771 B2Granted
Process for regenerating 2-chlorotrityl resins
AssigneeHoffmann-La Roche Inc.
InventorsKleomenis Barlos, Bernhard Knipp
Life of this patent
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Abstract
The present invention relates to a recycling process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) useful for solid phase peptide synthesis, wherein active chloride CTC resin is regenerated by reacting the spent resin with a chlorinating agent in organic solvent.
Claims6
A process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) of formula I
- wherein Ps is a polymeric support and n has the following meaning:
- 1≧n>0 comprising the reaction of solid phase bonded 2-chlorotrityl of formula II
- wherein R is OH or/and OC1-4-alkyl or/and NR′R″
- wherein R′ and R″ independently of each other represent C1-4-alkyl, or R′ and R″ together with the nitrogen to which they are bonded represent a 5 to 8 membered heterocyclic radical
- in the presence of a HCl and dioxane.
2 more elements
Dependencies are inferred from the claim text.