Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors

An ionic hydrophilic high molecular weight redox polymer for use in enzymatic electrochemical-based sensors employing a charged redox enzyme, the ionic hydrophilic high molecular weight redox polymer comprising:

• a hydrophilic polymer backbone that includes ionic portions;
• and
• a plurality of attached redox mediators covalently attached to the hydrophilic polymer backbone in a flexible pendant manner such that the redox mediators can segmentally diffuse between the charged redox enzyme and an electrode of the enzymatic electrochemical-based sensor,
• wherein the molecular weight of the ionic hydrophilic high molecular weight polymer is greater than 16 Kg/mol as a weight average molecular weight, and
• wherein an ionic charge of the ionic portions is predetermined to result in an affinity between the ionic portions and the charged redox enzyme of an enzymatic electrochemical-based sensor and that minimizes leaching of the redox enzyme and fosters activity between the redox enzyme and redox mediator.