Compositions and methods of their use for improving the condition and appearance of skin
AssigneeAvon Products, Inc.
InventorsLaurence Dryer, Dmitri Ptchelintsev
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods for treating, preventing and improving the condition and/or aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include active agents which increase expression levels of genes associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and/or aesthetic appearance of skin.
Claims13
A method of ameliorating, reducing, or treating progressive degradation of a dermal-epidermal junction and/or degradation of a cell-cell cohesion in skin, comprising topicafly applying to skin a topical composition comprising:
- (a) a cosmetically, dermatologically, pharmaceutically, or physiologically effective amount of an active agent, wherein said active agent is S-Methyl-L-Cysteine and S-Phenyl-L-Cysteine sufficient to increase expression levels of at least one gene selected from the group consisting of:
- Beta-catenin, Collagen 4, Collagen 7, Frizzled 10, Estrogen Receptor alpha, Hyaluronic acid synthase, and combinations thereof;
- and
- (b) a cosmetically, dermatologically, pharmaceutically, or physiologically acceptable vehicle, in an amount effective to ameliorate, reduce, or treat progressive degradation of a dermal-epidermal junction and/or degradation of a cell-cell cohesion in skin, wherein the progressive degradation of a dermal-epidermal junction and/or degradation of a cell-cell cohesion in skin is not hyperkeratosis.
A method of improving the condition and/or aesthetic appearance of skin comprising topically applying to skin a topical composition comprising;
- (a) a cosmetically, dermatologically, pharmaceutically, or physiologically effective amount of an active agent, wherein said active agent is S-Methyl-L-Cysteine and S-Phenyl-Cysteine sufficient to increase expression levels of at least one gene selected from the group consisting of Beta-catenin, Collagen 4, Collagen 7, Frizzled 10, Estrogen Receptor alpha, Hyaluronic acid synthase, and combinations thereof;
- and
- (b) a cosmetically, dermatologically, pharmaceutically, or physiologically acceptable vehicle, in an amount effective to improve the condition and/or aesthetic appearance of skin, wherein the condition is not hyperkeratosis.
Dependencies are inferred from the claim text.