4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity

A compound of the formula

• wherein Y is CH≡C—or CH≡C—CH2—;
• R3 is H or F;
• R is H, alkyl of 1 to 6 carbons, —CH2OR4, —CH2—O—COR4, or a cation of a pharmaceutically acceptable base, and
• R4 is alkyl having 1 to 6 carbons.

A pharmaceutical composition for administration to a mammal, comprising a pharmaceutically acceptable excipient and an effective dose of one or more compounds in accordance with the formula below, to inhibit the enzyme cytochrome P450RAI in said mammal in need of such inhibition

• wherein Z is COO or C≡C;
• R1 is alkyl having 1 to 6 carbons;
• R2 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, CF3, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons or alkylthio of 1 to 6 carbons;
• R3 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, CF3, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons or alkylthio of 1 to 6 carbons;
• m is an integer having the values of 0 to 6;
• n is an integer having the values of 0 to 2;
• o is an integer having the values 0 to 4;
• p is an integer having the values 0, 1, or 2;
• Y is CH≡C—, CH≡C—CH2—;
• CH2═CH—or —C≡N;
• R is H, alkyl of 1 to 6 carbons, —CH2OR4, —CH2,—O—COR4, or a cation of a pharmaceutically acceptable base, and
• R1 is alkyl having 1 to 6 carbons.