Tetrahydrocarbazole derivatives and their pharmaceutical use

A compound of formula (I):

• wherein:
• n is 0, 1, or 2;
• X is NH, Om;
• each R is the same or different and is independently selected from the group consisting
• of halogen, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, —R10cycloalkyl, Ay, —NHR10Ay, Het, —NHHet, —NHR10Het, —OR2, —OAy, —OHet, —R10OR2, —NR2R3, —NR2Ay, —R10NR2R3, —R10NR2Ay, —R10C(O)R2, —C(O)R2, —CO2R2, —R10CO2R2, —C(O)NR2R3, —C(O)Ay, —C(O)NR2Ay, —C(O)Het, —C(O)NHR10Het, —R10C(O)NR2R3, —C(S)NR2R3, —R10C(S)NR2R3, —R10NHC(NH)NR2R3, —C(NH)NR2R3, —R10C(NH)NR2R3, —S(O)2NR2R3, —S(O)2NR2Ay, —R10SO2NHCOR2, —R10SO2NR2R3, —R10SO2R2, —S(O)mR2, cyano, nitro, or azido;
• each R1 is the same or different and is independently selected from the group consisting of halogen, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, —R10cycloalkyl, Ay, —NHR10Ay, Het, —NHHet, —NHR10Het, —OR2, —OAy, —OHet, —R10OR2, —NR2R3, —NR2Ay, —R10NR2R3, —R10NR2Ay, —R10C(O)R2, —C(O)R2, —CO2R2, —R10CO2R2, —C(O)NR2R3, —C(O)Ay, —C(O)NR2Ay, —C(O)Het, —C(O)NHR10Het, —R10C(O)NR2R3, —C(S)NR2R3, —R10C(S)NR2R3, —R10NHC(NH)NR2R3, —C(NH)NR2R3, —R10C(NH)NR2R3, —S(O)2NR2R3, —S(O)2NR2Ay, —R10SO2NHCOR2, —R10SO2NR2R3, —R10SO2R2, —S(O)mR2, cyano, nitro, or azido;
• each m independently is 0, 1, or 2;
• each R10 is the same or different and is independently selected from alkylene, cycloalkylene, alkenylene, cycloalkenylene, and alkynylene;
• p and q are each independently selected from 0, 1, 2, 3, 4, or 5;
• each of R2 and R3 are the same or different and are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, —R10cycloalkyl, —R10OH, —R10(OR10)w, and —R10NR4R5;
• w is 1-10;
• each of R4 and R5 are the same or different and are independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, and alkynyl;
• Ay represents an aryl group;
• Het represents a 5- or 6-membered heterocyclyl or heteroaryl group;
• ring A is aryl or heteroaryl;
• or a
• pharmaceutically acceptable salts or solvate thereof.