Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)

A method for the treatment of cerebral thrombosis comprising administering to a mammal in need thereof a pharmaceutically effective amount of a compound of Formula I:

• wherein:
• R1, R2, R3, and R4 are each, independently, hydrogen, alkyl of 1-3 carbons, cycloalkyl of 3-5 carbon atoms, —CH2-cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-3 carbons, halogen, hydroxy, aryl optionally substituted with from 1 to 3 groups selected from R8, perfluoroalkyl of 1-3 carbons, alkoxy of 1-3 carbons, amino, alkylamino of 1-3 carbons, dialkylamino of 1-3 carbons, or perfluoroalkoxy of 1-3 carbons;
• R5 is hydrogen, alkyl of 1-6 carbons, perfluoroalkyl of 1-6 carbons, aryl substituted with R8, alkanoyl of 1-6 carbons, or aroyl optionally substituted with from 1 to 3 groups selected from R8;
• R6 is hydrogen, alkyl of 1-6 carbons, alkylaryl, benzyl substituted with R8, alkanoyl of 1-6 carbons, or aroyl optionally substituted with from 1 to 3 groups selected from R8;
• R7 is hydrogen, alkyl of 1-6 carbons, alkylaryl, or aryl optionally substituted with from 1 to 3 groups selected from R8;
• n is an integer of 0-6;
• A is COOH, or an acid mimic;
• R8 is hydrogen, alkyl of 1-3 carbons, cycloalkyl of 3-5 carbons, —CH2-cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-3 carbons, halogen, hydroxy, perfluoroalkyl of 1-3 carbons, alkoxy of 1-3 carbons, amino, alkylamino of 1-3 carbons, dialkylamino of 1-3 carbons, or perfluoroalkoxy of 1-3 carbons;
• or a pharmaceutically acceptable salt or ester form thereof.