Back to results
US 7,351,724 B2Granted
Oxadiazole ketone inhibitors of fatty acid amide hydrolase
AssigneeThe Scripps Research Institute
InventorDale L. Boger
Life of this patent
Estimating the term…
Abstract
Certain oxadiazole ketone compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as MS).
Claims8
A compound of Formula (I):
- wherein:
- Ar is a pyridinyl ring having a carbon as its point of attachment;
- A is a straight-chain C1-7alkylene having a carbon as its point of attachment to the carbon in the beta position, optionally having 1 or 2 carbon atoms each replaced with a sulfur, oxygen, or nitrogen atom;
- B is a straight-chain, branched, or cyclic C2-10alkylene, or, is an aryl, C2-10alkenyl, or C2-10alkynyl, where an sp2 hybridized carbon atom in said aryl, alkenyl, or alkynyl is covalently attached to A;
- or a pharmaceutically acceptable salt of said compound.
2 more elements
A compound selected from the group consisting of:
- 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]-heptan-1-one;
- 6-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]-hexan-1-one;
- 8-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]-octan-1-one;
- 9-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]-nonan-1-one;
- 1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]-octadec-9-en-1-one;
- 6-phenyl-1-[5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl]-hexan-1-one;
- 7-phenyl-1-[5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl]-heptan-1-one;
- 7-phenyl-1-[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]-heptan-1-one;
- and
- 6-phenoxy-1-(5-pyridin-2-yl-[1,3,4]oxadiazol-2-yl)-hexan-1-one.
7 more elements
Dependencies are inferred from the claim text.