US 7,351,723 B2 · Freeze-dried pantoprazole preparation and pantoprazole injection

Abstract

Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have advantageous properties when reconstituted for injection.

Claims14

Dependent claims

Lyophilized preparation consisting of:

(a) 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]-1H-benzimidazole (pantoprazole) or a solvate, hydrate, salt, hydrate of a salt or solvate of a salt thereof;
(b) ethylenediamine tetraacetic acid and/or a suitable salt thereof, and
(c) sodium hydroxide and/or sodium carbonate.

Dependencies are inferred from the claim text.

Facts

Application

10/855,703Filed 28 May 2004 · continuation

Priority

EP 0012556922 Nov 2000

Published

US 2004/0220228 A14 Nov 2004

Granted

1 Apr 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…
A61K 47/02
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents…:…

Family

PCT/EP01/13296Parent of this continuation-in-part · filed 17 Nov 2001

Application10/195,062Parent of this continuation · filed 15 Jul 2002

US 2004/0220228 A1Pre-grant publication · published 4 Nov 2004

US 6,780,881 B2Parent of this continuation-in-part

Application10/195,062Parent of this continuation-in-part

US 2003/0003058 A1Published application

US 7,351,723 B2This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

10/855,703Filed 28 May 2004 · continuation

Priority

EP 0012556922 Nov 2000

Published

US 2004/0220228 A14 Nov 2004

Granted

1 Apr 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…
A61K 47/02
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents…:…

Family

PCT/EP01/13296Parent of this continuation-in-part · filed 17 Nov 2001

Application10/195,062Parent of this continuation · filed 15 Jul 2002

US 2004/0220228 A1Pre-grant publication · published 4 Nov 2004

US 6,780,881 B2Parent of this continuation-in-part

Application10/195,062Parent of this continuation-in-part

US 2003/0003058 A1Published application

US 7,351,723 B2This patent

From the US filing history. Foreign family members aren’t listed.

Freeze-dried pantoprazole preparation and pantoprazole injection

Life of this patent

Abstract

Claims14

Freeze-dried pantoprazole preparation and pantoprazole injection

Life of this patent

Abstract

Claims14