Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them

An amino acid compound of formula (I)

• wherein,
• R1 is C1-15 alkyl, C1-8 alkoxy, phenyl, C3-8 cycloalkyl, C1-4 alkyl substituted with phenyl or C3-8 cycloalkyl, C1-4 alkoxy substituted with phenyl or C3-8 cycloalkyl, or C2-4 alkenyl substituted with phenyl or C3-8 cycloalkyl,
• wherein all the said phenyl and C3-8 cycloalkyl in R1 may be substituted with 1-3 substituent(s) selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, phenyl, phenoxy, benzyloxy, —SR5 (in which R5 is hydrogen or C1-4 alkyl), C2-5 acyl, halogen, C1-4 alkoxycarbonyl, nitro and —NR6R7 (in which R6 and R7 are independently, hydrogen, C1-4 alkyl or C1-4 alkoxycarbonyl),
• A is —CO—,
• R2 is hydrogen,
• D is C1-4 alkylene,
• E is —O—, —S—, —SO—, or —SO2—,
• R3 is carbocyclic ring or C1-4 alkyl substituted with carbocyclic ring,
• wherein the carbocyclic ring in R3 may be substituted with 1-3 substituent(s) selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, phenyl, phenoxy, benzyloxy, —SR13 (in which R13 is hydrogen or C1-4 alkyl), C2-5 acyl, halogen, C1-4 alkoxycarbonyl, nitro and —NR14 R15 (in which R14 and R15 are independently, hydrogen, C1-4 alkyl or C1-4 alkoxycarbonyl),
• J is J1 or J2,
• J1 is —O— or —NR16— (in which R16 is hydrogen or C1-4 alkyl),
• J2 is NR17— (in R17 alkyl substituted with phenyl), NR18R19 (in which R18 and R19 are independently, hydrogen or C1-4 alkyl), hydroxy, C1-4 alkoxy, —(C1-4 alkylene)-OH, —(C1-4 alkylene)-O—(C1-4 alkyl), —(C1-4 alkylene)-O—(C2-5 acyl), —NR20—NR21— (in which R20 and R21 are independently, hydrogen or C1-4 alkyl which may be substituted with one phenyl), —NR22—(C1-4 alkylene)-NR23— (in which R22 and R23 are independently, hydrogen or C1-4 alkyl which may be substituted with one phenyl), —NR24—(C1-4 alkylene)-O— (in which R24 is hydrogen or C1-4 alkyl which may be substituted with one phenyl) or —NR25—(C1-4 alkylene)-S— (in which R25 is hydrogen or C1-4 alkyl which may be substituted with one phenyl),
• R4 is R4-1, R4-2 or R4-3,
• R4-1 is piperidinyl which may be substituted with 1-3 substituent(s) selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, phenyl, phenoxy, benzyloxy, —SR29 (in which R29 is hydrogen or C1-4 alkyl), C2-5 acyl, halogen, 1-4 alkoxycarbonyl, nitro and —NR30R31 (in which R30 and R31 are independently, hydrogen, C1-4 alkyl or C1-4 alkoxycarbonyl, or R30 and R31 taken together with nitrogen atom to which they are attached represents 5-7-membered saturated heterocyclic ring necessarily containing one nitrogen atom and optionally further containing one nitrogen atom or one oxygen atom),
• R4-2 is piperidinyl, which is substituted with one hydroxy or one —O—(C1-4 alkylene)-O—(C1-4 alkyl) and may be substituted with further 1-2 substituent(s) selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, phenyl, phenoxy, benzyloxy, —SR35 (in which R35 is hydrogen or C1-4 alkyl), C2-5 acyl, halogen, C1-4 alkoxycarbonyl, nitro, —NR36R37 (in which R36 and R37 are independently, hydrogen, C1-4 alkyl or C1-4 alkoxycarbonyl, or R36 and R37 taken together with nitrogen atom to which they are attached represents 5-7-membered saturated heterocyclic ring necessarily containing one nitrogen atom and optionally further containing one nitrogen atom or one oxygen atom), hydroxy and —O—(C1-4 alkylene)-O—(C1-4 alkyl),
• R4-3 is -L-M, -L- is piperidinyl which may be substituted with 1-3 substituent(s),
• M is carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s) (with the proviso that when the carbocyclic ring of said carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s) is phenyl, said ring is substituted with at least one substituent(s), and that when the said heterocyclic ring of said carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s) is 5-7-membered saturated heterocyclic ring in which the nitrogen atom in the said heterocyclic ring is bonded to group L shown as
• and which may contain further one nitrogen atom or one oxygen atom, then such a ring is substituted with at least one substituent(s)), C1-4 alkyl substituted with 1-2 substituent(s) selected from the group consisting of carbocyclic ring which may be substituted with 1-3 substituent(s), and heterocyclic ring which may be substituted with 1-3 substituent(s), —O-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s)) (with the proviso that when the carbocyclic ring of said —O-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s) is phenyl, said ring is substituted with at least one substituent(s)), —S-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 of substituent(s)), —NR38-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 of substituent(s)) in which R38 is hydrogen or C1-4 alkyl which may be substituted with one phenyl, —O—CH2-(carbocyclic ring which may be substituted with 1-3 of substituent(s)) (with the proviso that when the carbocyclic ring of said —O—CH2-(carbocyclic ring which may be substituted with 1-3 of substituent(s) is phenyl, said ring is substituted with at least one substituent(s)), —O—(C2-4 alkylene)-(carbocyclic ring which may be substituted with 1-3 of substituent(s)), —O—(C1-4 alkylene)-(heterocyclic ring which may be substituted with 1-3 of substituent(s)), —S—(C1-4 alkylene)-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 of substituent(s)), —NR39-4 alkylene)-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s)) (in which R39 is hydrogen, C1-4 alkyl which may be substituted with one phenyl or C2-5 acyl which may be substituted with 1-3 of halogen) or —CO-(carbocyclic ring or heterocyclic ring which may be substituted with 1-3 substituent(s)), wherein the substituent(s) of the carboxylic ring and heterocyclic ring in L and M are selected from C1-4 alkyl, C2-4 alkenyl, hydroxy, C1-4 alkoxy, —(C1-4 alkylene)-OH, —O—(C1-4 alkylene)-O—(C1-4 alkyl), halogen, —NR40R41 (in which R40 and R41 are independently, hydrogen, C1-4 alkyl or C1-4 alkoxycarbonyl, or R40 and R41 taken together with nitrogen atom to which they are attached represents 5-7-membered saturated heterocyclic ring necessarily containing one nitrogen atom and optionally further containing one nitrogen atom or one oxygen atom), SR42 (in which R42 is hydrogen or C1-4 alkyl), nitro, trifluoromethyl, C1-4 alkoxycarbonyl, oxo and C2-5 acyl, with the proviso that when J is J1, R4 does not represent R4-1,
• or a pharmaceutically acceptable salt thereof.