Spiroazacyclic compounds as monoamine receptor modulators

A compound of formula I, salts and stereoisomers thereof

• wherein X is OCH2;
• Y is selected from the group consisting of O and S;
• Z is CH;
• R1 is hydrogen, or an optionally substituted substituent selected from the group consisting of C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, aryl, heteroaryl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), heterocyclyl(C1-6 alkyl), hydroxy(C1-6 alkyl), amino(C1-6 alkyl), and halo(C1-6 alkyl);
• m is 0;
• R4 is absent;
• R5 and R6 are optionally substituted substituents independently selected from the group consisting of aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), and heterocyclyl(C1-6 alkyl);
• R2 and R3 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and optionally substituted C1-6 alkyl or selected such that R2 and R3 together form a ring system such that
• is selected from the group consisting of
• wherein R7 and R8 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and optionally substituted C1-6 alkyl.