Carboxylic acid compounds and a pharmaceutical agent comprising the compound as the active ingredient

A carboxylic acid compound represented by formula (I):

• wherein R1 represents (1) a hydrogen atom, (2) C1-4 alkyl, (3) C2-4 alkenyl or (4) benzyl;
• E represents —C(═O)—, —SO2— or —CH2—;
• R2 represents (1) a halogen atom, (2) C1-6 alkyl, (3) C1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl, (9) nitro, (10) —NR6R7 or (11) C1-4 alkyl substituted with —OR8;
• R3 represents (1) a halogen atom, (2) C1-6 alky, (3) C1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl, (9) nitro, (10) —NR6R7 or (11) C1-4 alkyl substituted with —OR8;
• R6 and R7 each independently represents a hydrogen atom or C1-4 alkyl;
• R8 represents C1-4 alkyl, phenyl or pyridyl;
• R4 represents (1) a hydrogen atom, (2) C1-6 alkyl or (3) benzyl;
• R5 represents (1) C1-6 alkyl, (2) C1-10 alkoxy, (3) C1-6 alkyl substituted with C1-6 alkoxy, (4) a halogen atom, (5) hydroxyl, (6) trihalomethyl, (7) nitro, (8) —NR9R10, (9) phenyl, (10) phenoxy, (11) oxo, (12) C2-6 acyl, (13) cyano or (14) —SO2R11;
• R9 and R10 each independently represents a hydrogen atom or C1-4 alkyl;
• R11 represents C1-6 alkyl;
• represents a C5-12 monocyclic or bicyclic carbon ring or a 5- to 12-membered monocyclic or bicyclic hetero ring aryl having hetero atom(s) selected from one to four nitrogen atom(s), one to two oxygen atom(s) and/or one to two sulfur atom(s) and such hetero ring is saturated either partially or wholly;
• G represents (1) C1-6 alkylene having 0 to 2 hetero atom(s) selected from an nitrogen atom, an oxygen atom and a sulfur atom, (2) C2-6 alkenylene having 0 to 2 hetero atom(s) selected from an nitrogen atom, an oxygen atom and a sulfur atom or (3) C2-6 alkynylene having 0 to 2 a hetero atom(s) selected from an nitrogen atom, an oxygen atom and a sulfur atom;
• represents a dihydrobenzoxazine ring;
• m represents 0 or an integer of 1 to 4;
• n represents 0 or an integer of 1 to 4;
• and
• i represents 0 or an integer of 1 to 11;
• wherein when m is 2 or more, R2 are the same or different;
• when n is 2 or more, R3 are the same or different;
• and i is 2 or more, R5 are the same or different)
• or a pharmaceutically acceptable salt thereof.