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US 7,351,701 B2Granted
Therapeutic compounds
AssigneesCancer Research Technology Limited, Pfizer Inc.
InventorsThomas Helleday, Nicola Curtin
Life of this patent
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Abstract
The invention relates to trycyclic lactam indole derivatives and triacyclic lactam benzimodole derivatives and their use in inhibiting the activity of PARP enzyme. The invention also relates to the use of these compounds in the preparation of medicaments.
Claims6
A method for treating cancer in a mammal, wherein the cancer is caused by a genetic defect in a gene that mediates homologous recombination, wherein the gene is at least one of BRCA1 and BRCA2, the method comprising:
- selecting the mammal having the genetic defect;
- and
- administering to the mammal a compound selected from the group consisting of a compound of the formula I, formula II and formula III:
- or a pharmaceutically acceptable salt thereof,
- wherein the compound is used as a direct cytotoxic agent.
2 more elements
Dependencies are inferred from the claim text.