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US 7,351,697 B2Granted
Tumor-specific vector for gene therapy
OwnerJan-Heinerr Küpper, Ralph Meyer +2inventors
InventorsJan-Heinerr Küpper, Ralph Meyer, Mirella Meyer-Ficca, Reinhard Kandolf
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Abstract
The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence thereof. The gene is controlled by the promoter for the catalytic subunit of the telomerase or by the promoter for cyclin A.
Claims20
A vector for treating tumors by gene therapy, comprising a DNA sequence comprising
- a) a first sequence encoding T7 RNA polymerase under control of a tissue-specific promoter that is a telomerase catalytic subunit promoter or a cyclin-A promoter;
- b) at least one therapeutic gene under control of a first T7 promoter, wherein the therapeutic gene encodes a protein selected from the group consisting of:
- cytosine deaminase (CD), herpes simplex-virus thymidine kinase (HSV-TK), DNA-binding domain (DBD) of poly(ADP-ribose) polymerase (PARP), cytotoxic protease 2A and 3C;
- or a fusion protein comprising at least two proteins selected from the group of proteins;
- and
- c) a second sequence encoding T7 RNA polymerase under control of second T7 promoter.
3 more elements
Dependencies are inferred from the claim text.