Human NK-3 related prostate specific gene-1
AssigneeHuman Genome Sciences, Inc.
InventorsWei-Wu He, Kenneth C. Carter
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Abstract
The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.
Claims11
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues 1 to 234 of SEQ ID NO:2;
- (b) amino acid residues 2 to 234 of SEQ ID NO:2;
- (c) amino acid residues 1 to 234 of SEQ ID NO:4;
- and
- (d) amino acid residues 2 to 234 of SEQ ID NO:4.
Dependencies are inferred from the claim text.