Compositions and methods for less immunogenic protein formulations
AssigneeThe Research Foundation of State University of New York
InventorsSathyamangalam V. Balasubramanian, Robert M. Straubinger, Vivek S. Purohit, Karthik Ramani
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Abstract
Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes.
Claims1
A method for reducing the immunogenicity of Factor VIII comprising the steps of forming a complex of Factor VIII with a binding agent, wherein the binding agent is O-Phospho-L-Serine (OPLS), wherein the immunogenicity of Factor VIII upon administration to an individual is reduced when complexed with the binding agent.
Dependencies are inferred from the claim text.