Antibodies to G protein-coupled receptor
AssigneeAgensys, Inc.
InventorsArthur B. Raitano, Daniel E. H. Afar, Aya Jakobovits, Mary Faris, Rene S. Hubert, Steven Chappell Mitchell, Douglas Saffran
Life of this patent
Estimating the term…
Abstract
A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.
Claims10
Isolated antibodies or antigen binding fragments thereof specifically immunoreactive with a PHOR-1 protein of SEQ ID NO:
- 2 or the polypeptide encoded by the cDNA contained in plasmid 101P3A11 deposited with the American Type Culture Collection (ATCC) as Accession No. PTA-312.
Dependencies are inferred from the claim text.