Methods for processing biological materials using peelable and resealable devices

A method for performing at least one bulk process step on a biological material comprising:

• a) chemically treating a base plate to enhance immobilization of kinase substrates thereon with a solution of mixed self-assembled monolayer (SAM) comprising about 0.1 to 20% maleimide-terminal groups in a background of tri(ethylene glycol) terminal groups;
• b) placing a first removable member on the base plate for establishing self-sealing contact of the first removable member on the base plate,
• the first removable member being adapted to repeatedly self-seal on the base plate,
• the first removable member further defining a plurality of first orifices therein, each having a plurality of first walls bounding respective ones of the plurality of first orifices,
• the first removable member further being configured such that, when placed in self-sealing contact with the base plate, the first removable member defines a plurality of first wells therewith corresponding to respective ones of the plurality of first orifices;
• c) immobilizing a biological material on a plurality of first regions of the base plate exposed by the plurality of first orifices;
• d) removing the first removable member from the base plate such that the biological material is arrayed on the base plate in an array that corresponds to the plurality of first orifices;
• and
• e) performing at least one bulk process step on the entire array of biological material on the base plate simultaneously.