Process for the production of β-amino acids using acylase
AssigneeAjinomoto Co., Inc.
InventorsTsuyoshi Nakamatsu, Hisashi Kawasaki, Kunihiko Watanabe, Masakazu Nakazawa, Kunisuke Izawa
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Abstract
The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a Burkholderia sp. which produces both an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an S-β-amino acid and an acylase having an asymmetric hydrolysis activity of an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a process for the selective production of an S-, or R-β-amino acid using the above strains.
Claims6
An isolated Variovorax sp. strain comprising a 16SrDNA sequence of SEQ ID NO:
- 1, which is able to produce an acylase comprising an asymmetric hydrolysis activity on an N-acetyl β-amino acid so that an R-β-amino acid is selectively produced.
Isolated strain 119L (AJ 110348, FERM ABP-10367).
An isolated Burkholderia sp. strain comprising a 16SrDNA sequence of SEQ ID NO:
- 2, which is able to produce both an acylase comprising an asymmetric hydrolysis activity on an N-acetyl β-amino acid so that an S-β-amino acid is selectively produced, and an acylase comprising an asymmetric hydrolysis activity on an N-acetyl β-amino acid so that an R-β-amino acid is selectively produced.
Isolated strain 130F (AJ 110349, FERM ABP-10366).
Dependencies are inferred from the claim text.