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US 7,351,553 B2Granted
BK beta subunits of Slo family potassium channels
AssigneeIcagen, Inc.
InventorsTimothy James Jegla, Alan Wickenden, Yi Liu
Life of this patent
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.
Claims6
An isolated nucleic acid encoding a beta subunit polypeptide of a potassium channel, wherein the beta subunit polypeptide:
- (i) forms, with at least four alpha subunit polypeptides, a Slo potassium channel;
- and
- (ii) comprises an amino acid sequence that has greater than 90% identity to SEQ ID NO:3, and wherein said beta subunit polypeptide slows activation of the Slo current.
Dependencies are inferred from the claim text.