Modified pro-α peptides and their uses
AssigneeThe University of Manchester
InventorsKarl Kadler, Neil Bulleid, Gillian Ashcroft
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Abstract
A modified pro-α chain comprising a triple helix forming domain linked to a polypeptide from at least part of a laminin glycoprotein. The pro-α chain may form part of a procollagen molecule that has the N-terminal domain retained. The procollagen molecules may be incorporated into collagen polymers, matrices and gels and be used for such applications as wound healing.
Claims88
A modified pro-α chain comprising at least part of a laminin glycoprotein wherein the at least part of a laminin glycoprotein is placed N-terminal to a triple helical forming domain of the pro-α chain.
A procollagen molecule comprising a trimer of pro-α chains wherein the molecule includes one of SEQ ID NO:
- 10 or SEQ ID NO:
- 14.
A collagen polymer comprising at least one modified collagen monomer, wherein said modified collagen monomer comprises at least part of a laminin glycoprotein placed N-terminal to a triple helical forming domain in a collagen monomer.
Dependencies are inferred from the claim text.