Exoenzyme toxin of Aeromonas salmonicida, and uses thereof
AssigneeUniversitäT Bern
InventorsJoachim Frey, Peter Kuhnert, Michael A. Kuzyk, Jan Burian, Martin Braun
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Abstract
A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
Claims11
An isolated nucleic acid molecule, encoding a polypeptide having at least 95% amino acid sequence identity to the amino acid sequence of SEQ ID NO:2, wherein the polypeptide has ADP-ribosyltransferase activity, or the fully complementary sequence thereof.
An isolated nucleic acid molecule, or a fully complementary sequence thereof, that hybridized under a stringent condition to a nucleotide sequence or its full complement, wherein the nucleotide sequence encodes a polypeptide having the amino acid sequence of SEQ ID NO:2, wherein the stringent condition comprises washing at 20° C. with 0.2×SSC and 0.1% SDS.
Dependencies are inferred from the claim text.