Back to results
US 7,351,543 B2Granted
Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma
AssigneeGenentech, Inc.
InventorsAudrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
Life of this patent
Estimating the term…
Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims9
A method for the diagnosis of melanoma comprising:
- (a) identifying a patient suspected of having neoplastic disease;
- and
- (b) detecting expression of a polypeptide having the amino acid sequence of SEQ ID NO:
- 24 in a test sample from said patient,
- wherein lower expression of said polypeptide in said test sample as compared to a normal control sample indicates the presence of melanoma.
2 more elements
Dependencies are inferred from the claim text.