Method for diagnosing a renal disorder
AssigneeFuso Pharmaceutical Industries, Ltd.
InventorsKunio Miwa, Junko Sugatani
Life of this patent
Estimating the term…
Abstract
Methods for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic E. coli infectious disease at an early stage, and for diagnosing the severity of these diseases are provided. Detection of excretion of AQP2 and/or molecules derived therefrom into urine of a subject, or determination of the amount of excretion of the same is conducted to diagnose the morbidity or the severity of renal disorder, hemolytic uremic syndrome and enterohemorrhagic E. coli infectious disease of the subject. For the detection and determination of AQP2, an immunochemical process may be suitably employed in which an antibody that specifically recognizes AQP2.
Claims7
A method for diagnosing a renal disorder caused by verotoxin-producing Escherichia coli (E. coli) in a subject suffering from an E. coli infection, the method comprising
- measuring aquaporin 2 (AQP2) in the urine of a subject infected with E. coli;
- and
- diagnosing a renal disorder caused by verotoxin-producing Escherichia coli E. coli in the subject wherein an elevated level of AQP2 in the urine of the subject is indicative of a renal disorder caused by verotoxin-producing E. coli in said subject.
Dependencies are inferred from the claim text.