US 7,351,531 B2 · Molecules capable of binding to telomere and the like and method with the use of the same

Abstract

A method of forming a self-connective structure (a hairpin structure, a four-stranded structure, etc.) of a single-stranded oligonucleotide chain by forming a mimetic base pair of a mismatch base pair failing to form any normal base pair among base pairs of the single-stranded oligonucleotide chain with the use of a compounds represented by the following general formula (I): A-L-B (I) wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair failing to form any normal base pair; B represents a chemical structural moiety capable of forming a pair with the other base of the base pair failing to form any normal base pair; and L represents a linker structure by which the chemical structures A and B are linked to each other; and a method of inhibiting the activity of enzyme according to the previous method.

Claims11

Dependent claims

A method for forming a mimetic base pair at a base pair that fails to form any normal base pair among the base pairs of a single-stranded oligonucleotide chain comprising the steps of:

(1) providing a compound represented by the formula A-L-B, wherein A represents a chemical structural moiety capable of forming a pair with one base of the base pair that fails to form a normal base pair, B represents a chemical structural moiety capable of forming, a pair with another base of the base pair that fails to form a normal base pair, and L represents a linker structure that binds the moieties A and B;
and wherein said compound is characterized to form a mimetic base pair in a single-stranded oligonucleotide chain by a hydrogen bond formed between bases and the moieties A and B and a stabilization of the moieties A and B results from a stacking effect derived from the bases in the vicinity of the moiety B, and
(2) forming the mimetic base pair at a base pair that fails to form a normal base pair among the base pairs of a single stranded oligonucleotide chain.

Dependencies are inferred from the claim text.

Molecules capable of binding to telomere and the like and method with the use of the same

Life of this patent

Molecules capable of binding to telomere and the like and method with the use of the same

Life of this patent

Abstract

Claims11