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US 7,351,423 B2Granted
Musculo-skeletal implant having a bioactive gradient
AssigneeDePuy Spine, Inc.
InventorsSudhakar Kadiyala, Francois Binette, Cynthia Marie Coleman, Theresa Adams Kapur
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Abstract
This invention relates to an implant for a musculoskeletal defect having a bioactive agent having a concentration gradient.
Claims24
An implant for repair of a musculoskeletal defect comprising:
- a) a foam matrix having a central region, an upper region, a lower region and a peripheral region, and
- b) a first bioactive agent present within a first of the regions of the foam matrix,
- c) a second bioactive agent present within a second of the regions of the foam matrix,
- wherein the presence of the bioactive agents in different regions of the foam matrix is characterized by different controlled, gradual spatial concentration gradients.
1 more element
Dependencies are inferred from the claim text.