Vaccines comprising acapsular P. multocida hyaE deletion mutants
AssigneeThe United States of America as represented by the Department of Agriculture
InventorsRobert E. Briggs, Fred M. Tatum
Life of this patent
Estimating the term…
Abstract
Acapsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent or reduce the severity of hemorrhagic septicemia or pneumonia in mammals, particularly livestock, ungulates, and companion animals, or fowl cholera in birds, particularly poultry.
Claims78
An isolated Pasteurellaceae multocida (P. multocida) bacterium of serogroup A which comprises a hyaE gene comprising a deletion in its coding region, wherein the deletion results in an acapsular phenotype of the bacterium, thereby attenuating the bacterium.
Dependencies are inferred from the claim text.