Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans

A composition comprising:

• (1) a radiopharmaceutical precursor comprising a chelator not covalently linked to a targeting moiety or domain;
• and (2) a stabilizing amount of a hydrophilic 6-hydroxy-chroman derivative of the formula:
• wherein
• one of Y or Z is selected from the group consisting of O, S, C═O, and (CHR3)n, where n is an integer from 0 to 3, and the other of Y or Z is selected from the group consisting of C═O and (CHR3)n where n is an integer from 0 to 3;
• each R3 group is independently selected from the group consisting of H, alkyl, halogen, —OR4, —SO3H, —SO3R4, —S(O)mR4, —COOR4, —NO2, —CONHm(R4)2-m, —NHm(R4)2-m, —COR4, —CH2OR4, —COR5, —SO2NHm(R4)2-m, —R5, and —CH2R5, where m is an integer from 0 to 2;
• R4 is H or C1 to C3 alkyl;
• and
• R5 is selected from the group consisting of a monosaccharide, disaccharide, and a hydrophilic peptide sequence of up to 5 amino acids comprising at least one hydrophilic amino acid residue.