US 7,351,280 B2 · Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment

Abstract

A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.

Claims19

Dependent claims

A self-setting calcium phosphate cement composition comprising a mixture of a powder and an aqueous solution which results in the formation of a poorly crystalline apatite similar to bone apatite as the end product of the self-setting;

the said powder phase comprising calcium phosphate compounds of differing rates of resorbability, a fraction of said powder phase comprising α-TCP or TTCP, macroporous biphasic calcium phosphate (BCP) granules consisting of a mixture of HA and β-TCP, and ACP or stabilized ACP;
and a fraction of 1-10 wt% of said powder phase comprising one or more members selected from the group consisting of monocalcum phosphate, monocalcium phosphate monohydrate, calcium carbonate, and ACCP.

Dependencies are inferred from the claim text.

Facts

Application

11/054,623Filed 9 Feb 2005 · us provisional application

Priority

10 Feb 2004

Published

US 2005/0199156 A115 Sep 2005

Granted

1 Apr 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C04B 28/344
Containing cold phosphate binders: the phosphate binder being present in the starting composition solely as one or more phosphates
A61L 24/02
Surgical adhesives or cements; Adhesives for colostomy devices: containing inorganic materials
A61L 27/12
Inorganic materials: phosphorus-containing materials, e.g. apatite
A61L 2430/02
Materials or treatment for tissue regeneration: for reconstruction of bones; weight-bearing implants

Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment

Life of this patent

Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment

Life of this patent

Abstract

Claims19