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US 7,351,249 B2Granted
Systems, methods, and compositions for achieving closure of suture sites
AssigneeNeoMend, Inc.
InventorsOlexander Hnojewyj, Bruce Addis, Daniel Browne, David Cheung
Life of this patent
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Abstract
Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.
Claims10
A method for sealing a suture knot comprising the steps of
- placing a suture loop through tissue to join tissue,
- tying the suture loop to form a suture knot, and
- discharging a liquid closure material comprising an electrophilic component comprising a hydrophilic, biocompatible polymer that is electrophilically derivatized with a functionality of at least three and a solution containing a nucleophilic component comprising recombinant or natural serum albumin in a concentration of 25% or less and a buffer component adjacent the suture knot, the liquid closure material cross-linking after discharge to form a solid closure adjacent the suture knot having cohesive and tissue adhesive strength to impede blood flow without clot formation.
A method for sealing a puncture site in a blood vessel comprising the steps of
- placing a suture loop through tissue on opposite sides of the puncture site,
- tying the suture loop to form a suture knot at the puncture site, and
- discharging a liquid closure material comprising an electrophilic component comprising a hydrophilic, biocompatible polymer that is electrophilically derivatized with a functionality of at least three and a solution containing a nucleophilic component comprising recombinant or natural serum albumin in a concentration of 25% or less and a buffer component adjacent the suture knot, the liquid closure material cross-linking after discharge to form a solid closure adjacent the suture knot having cohesive and tissue adhesive strength to impede blood flow without clot formation.
Dependencies are inferred from the claim text.