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US 7,348,155 B2Granted
Method for identifying compounds for treating aging processes in the coronary circulatory system
AssigneeSanofi-Aventis Deutschland GmbH
InventorsEvi Kostenis, Andreas Busch, Vera Regitz-Zagrosek
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Abstract
The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or breakdown of the extracellular matrix being influenced.
Claims8
A method for identifying a compound that modifies the activity of urotensin II receptor resulting in a change in activity of a gene or activity or quantity of a gene product comprising:
- a] providing a cell in which urotensin II receptor is expressed,
- b] providing said compound,
- c] contacting said cell from a] with said compound from b],
- d] measuring the activity of the gene or activity or quantity of a gene product wherein the gene or the gene product is selected from the group consisting of metalloproteinase type 2 (MMP2,), transforming growth factor beta 1 (TGFβ1) and connective tissue growth factor (CTGF),
- e] measuring the activity of the gene or activity or quantity of a gene product from a control cell not contacted with said compound, and
- f] comparing the measurement from d] and e] wherein a difference obtained from f] identifies said compound as changing the activity of the gene or activity or quantity of a gene product resulting from modification of urotensin II receptor activity.
3 more elements
Dependencies are inferred from the claim text.