Adhesion barriers applicable by minimally invasive surgery and methods of use thereof

A method of coating a patient's abdominopelvic tissue comprising:

• delivering to the abdominopelvic tissue, using minimally invasive surgical techniques, a first synthetic reactive precursor species and a second reactive precursor species and
• mixing the reactive precursor species to interact with each other to form a biocompatible, covalently crosslinked, synthetic hydrogel in situ within about one minute of the mixing that adheres to the abdominopelvic tissue, is hydrolytically biodegraded, and is effective in humans to reduce the risk of patient injury caused by adhesions,
• wherein the first reactive precursor species comprises nucleophilic functional groups and the second reactive precursor species comprises electrophilic functional groups and the mixing of the reactive precursor species causes the electrophilic functional groups and the nucleophilic functional groups to form covalent bonds with each other to form the hydrogel wherein the hydrogel is hydrolytically biodegraded in less than about 30 days and wherein the reactive precursor species are delivered to the tissue using a spray applicator.