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US 7,345,175 B2Granted
Biphenyl derivatives
AssigneeTheravance, Inc.
InventorsMathai Mammen, Adam Hughes, Yan Chen
Life of this patent
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Abstract
This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
Claims17
A compound of the formula:
- wherein
- o is an integer from 2 to 7;
- p is an integer from 1 to 6;
- provided that o+p is an integer from 3 to 8;
- the phen-1,4-ylene group is optionally substituted with from 1 to 4 substituents independently selected from halo, (1-4C)alkyl, (1-4C)alkoxy, —S-(1-4C)alkyl, —S(O)-(1-4C)alkyl, —S(O)2-(1-4C)alkyl, —C(O)O(1-4C)alkyl, carboxy, cyano, hydroxy, nitro, trifluoromethyl and trifluoromethoxy;
- or a pharmaceutically acceptable salt or solvate or stereoisomer thereof.
3 more elements
Dependencies are inferred from the claim text.